Oxidative stress in athletes: From the scientific basis to practical aspects
Apstrakt
Oxidative stress, which occurs as a result of physical exercise, has been intensively investigated in the last two decades. A large number of studies have been done on humans and in animal models, which resulted in clarification of the mechanism of free radical generation during exercise. Free radicals, unstable and reactive molecules that can be involved in cellular damage, are mainly generated by the mitochondria, xanthine oxidase, and neutrophils and other phagocytes. Increased production of free radicals during exercise is followed by the enhanced activity of the endogenous antioxidant defense system, which consists of enzymes and non-enzymatic substances. Very important results of previous studies have been related to adaptation mechanisms activated in response to increased oxidative stress during exercise. In addition to mitochondrial biogenesis and synthesis of new components of the respiratory chain to match higher energy demands, adaptation to regular physical exercise involve...s an increased expression of genes responsible for antioxidant enzyme synthesis. Also, great attention has been paid to the use of antioxidant supplements. The importance and effect of supplementation with dietary antioxidants depend on several factors such as intensity, frequency and mode of exercise as well as on the type and dose of the antioxidants used. Applying the results of previous research and monitoring the parameters of oxidative stress and antioxidative defense could help health professionals in understanding the medical condition of the athlete.
Ključne reči:
Free radicals / antioxidative defense / exercise / adaptive responses / dietary antioxidantsIzvor:
Serbian Journal of Sports sciences, 2014, 8, 1, 11-22Izdavač:
- Sportska akademija, Beograd
Institucija/grupa
PharmacyTY - JOUR AU - Martinović, Jelena AU - Dopsaj, Violeta PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2123 AB - Oxidative stress, which occurs as a result of physical exercise, has been intensively investigated in the last two decades. A large number of studies have been done on humans and in animal models, which resulted in clarification of the mechanism of free radical generation during exercise. Free radicals, unstable and reactive molecules that can be involved in cellular damage, are mainly generated by the mitochondria, xanthine oxidase, and neutrophils and other phagocytes. Increased production of free radicals during exercise is followed by the enhanced activity of the endogenous antioxidant defense system, which consists of enzymes and non-enzymatic substances. Very important results of previous studies have been related to adaptation mechanisms activated in response to increased oxidative stress during exercise. In addition to mitochondrial biogenesis and synthesis of new components of the respiratory chain to match higher energy demands, adaptation to regular physical exercise involves an increased expression of genes responsible for antioxidant enzyme synthesis. Also, great attention has been paid to the use of antioxidant supplements. The importance and effect of supplementation with dietary antioxidants depend on several factors such as intensity, frequency and mode of exercise as well as on the type and dose of the antioxidants used. Applying the results of previous research and monitoring the parameters of oxidative stress and antioxidative defense could help health professionals in understanding the medical condition of the athlete. PB - Sportska akademija, Beograd T2 - Serbian Journal of Sports sciences T1 - Oxidative stress in athletes: From the scientific basis to practical aspects VL - 8 IS - 1 SP - 11 EP - 22 UR - https://hdl.handle.net/21.15107/rcub_farfar_2123 ER -
@article{ author = "Martinović, Jelena and Dopsaj, Violeta", year = "2014", abstract = "Oxidative stress, which occurs as a result of physical exercise, has been intensively investigated in the last two decades. A large number of studies have been done on humans and in animal models, which resulted in clarification of the mechanism of free radical generation during exercise. Free radicals, unstable and reactive molecules that can be involved in cellular damage, are mainly generated by the mitochondria, xanthine oxidase, and neutrophils and other phagocytes. Increased production of free radicals during exercise is followed by the enhanced activity of the endogenous antioxidant defense system, which consists of enzymes and non-enzymatic substances. Very important results of previous studies have been related to adaptation mechanisms activated in response to increased oxidative stress during exercise. In addition to mitochondrial biogenesis and synthesis of new components of the respiratory chain to match higher energy demands, adaptation to regular physical exercise involves an increased expression of genes responsible for antioxidant enzyme synthesis. Also, great attention has been paid to the use of antioxidant supplements. The importance and effect of supplementation with dietary antioxidants depend on several factors such as intensity, frequency and mode of exercise as well as on the type and dose of the antioxidants used. Applying the results of previous research and monitoring the parameters of oxidative stress and antioxidative defense could help health professionals in understanding the medical condition of the athlete.", publisher = "Sportska akademija, Beograd", journal = "Serbian Journal of Sports sciences", title = "Oxidative stress in athletes: From the scientific basis to practical aspects", volume = "8", number = "1", pages = "11-22", url = "https://hdl.handle.net/21.15107/rcub_farfar_2123" }
Martinović, J.,& Dopsaj, V.. (2014). Oxidative stress in athletes: From the scientific basis to practical aspects. in Serbian Journal of Sports sciences Sportska akademija, Beograd., 8(1), 11-22. https://hdl.handle.net/21.15107/rcub_farfar_2123
Martinović J, Dopsaj V. Oxidative stress in athletes: From the scientific basis to practical aspects. in Serbian Journal of Sports sciences. 2014;8(1):11-22. https://hdl.handle.net/21.15107/rcub_farfar_2123 .
Martinović, Jelena, Dopsaj, Violeta, "Oxidative stress in athletes: From the scientific basis to practical aspects" in Serbian Journal of Sports sciences, 8, no. 1 (2014):11-22, https://hdl.handle.net/21.15107/rcub_farfar_2123 .