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The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis
dc.creator | Culafić-Vojinović, Violeta | |
dc.creator | Ćulafić, Đorđe | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Petakov, Milan | |
dc.creator | Đurović-Nikolić, Marina | |
dc.creator | Vasić, Jelena | |
dc.creator | Mirković, Duško | |
dc.creator | Mijac, Dragana | |
dc.creator | Stulić, Miloš | |
dc.date.accessioned | 2019-09-02T11:40:11Z | |
dc.date.available | 2019-09-02T11:40:11Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2146 | |
dc.description.abstract | Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije, Beograd i Versita | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Medical Biochemistry | |
dc.subject | liver cirrhosis | en |
dc.subject | osteoporosis | en |
dc.subject | osteocalcin | en |
dc.subject | beta-CTX | en |
dc.title | The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мијац, Драгана; Васић, Јелена; Игњатовић, Светлана; Цулафић-Војиновић, Виолета; Ђуровић-Николић, Марина; Петаков, Милан; Ћулафић, Ђорђе; Мирковић, Душко; Стулић, Милош; | |
dc.citation.volume | 33 | |
dc.citation.issue | 2 | |
dc.citation.spage | 149 | |
dc.citation.epage | 155 | |
dc.citation.other | 33(2): 149-155 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000332683700003 | |
dc.identifier.doi | 10.2478/jomb-2013-0025 | |
dc.identifier.scopus | 2-s2.0-84896860607 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/871/2144.pdf | |
dc.type.version | publishedVersion |