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Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients
dc.creator | Vekić, Jelena | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Damjanović, Tatjana | |
dc.creator | Šuvakov, Sonja | |
dc.creator | Matić, Marija | |
dc.creator | Savić-Radojević, Ana | |
dc.creator | Simić, Tatjana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Gojković, Tamara | |
dc.creator | Spasić, Slavica | |
dc.creator | Dimković, Nada | |
dc.date.accessioned | 2019-09-02T11:40:27Z | |
dc.date.available | 2019-09-02T11:40:27Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2157 | |
dc.description.abstract | Objectives: End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD. Design and methods: GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods. Results: GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P lt 0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P lt 0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P lt 0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P lt 0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P lt 0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P lt 0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions. Conclusions: Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Glutathione-S-transferase polymorphism | en |
dc.subject | Small | en |
dc.subject | Dense LDL | en |
dc.subject | HDL subclasses | en |
dc.subject | End-stage renal disease | en |
dc.subject | Cardiovascular disease risk | en |
dc.title | Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Матић, Марија; Векић, Јелена; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Гојковић, Тамара; Дамјановић, Татјана; Симић, Татјана; Шуваков, Соња; Спасић, Славица; Димковић, Нада; Савић-Радојевић, Aна; Јелић-Ивановић, Зорана; | |
dc.citation.volume | 47 | |
dc.citation.issue | 6 | |
dc.citation.spage | 398 | |
dc.citation.epage | 403 | |
dc.citation.other | 47(6): 398-403 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000333763300014 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2013.11.011 | |
dc.identifier.pmid | 24291050 | |
dc.identifier.scopus | 2-s2.0-84897112913 | |
dc.type.version | publishedVersion |