Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)
Autori
Krivokuća, MarijaNiketić, Marjan
Milenković, Marina
Golić, Nataša
Masia, Carla
Scaltrito, Maria Maddalena
Sisto, Francesca
Kundaković, Tatjana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu... g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL.
Ključne reči:
Alchemilla sp. / Ellagic acid / Helicobacter pylori / Quercetin-3-O-beta-D-glucosideIzvor:
Natural Product Communications, 2015, 10, 8, 1369-1371Izdavač:
- Natural Products Inc, Westerville
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-MESTD-Basic Research (BR or ON)-173021)
- Biljni i sintetički bioaktivni proizvodi novije generacije (RS-MESTD-Technological Development (TD or TR)-34012)
Napomena:
- Peer-reviewd.manuscript: http://farfar.pharmacy.bg.ac.rs/handle/123456789/3537
Institucija/grupa
PharmacyTY - JOUR AU - Krivokuća, Marija AU - Niketić, Marjan AU - Milenković, Marina AU - Golić, Nataša AU - Masia, Carla AU - Scaltrito, Maria Maddalena AU - Sisto, Francesca AU - Kundaković, Tatjana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2436 AB - The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae) VL - 10 IS - 8 SP - 1369 EP - 1371 UR - https://hdl.handle.net/21.15107/rcub_farfar_2436 ER -
@article{ author = "Krivokuća, Marija and Niketić, Marjan and Milenković, Marina and Golić, Nataša and Masia, Carla and Scaltrito, Maria Maddalena and Sisto, Francesca and Kundaković, Tatjana", year = "2015", abstract = "The present study evaluated the anti-Helicobacter pylori activity of Alchemilla glabra Neygenf. (A. sect. Alchemilla), A. monticola Opiz (A. sect. Plicatae S.E. Frohner), A. fissa Gunther & Schummel (A. sect. Calycinae (Buser) Buser) and A. viridiflora Rothm. (A. sect. Calycinae), and identified ellagic acid and quercetin-3-O-beta-D-glucoside. Anti-H. pylori activity was tested against ten clinical isolates and one reference strain (ATCC 43504). The methanol extracts were more active than the dichloromethane and cyclohexane extracts. The ranges of concentrations were between 4 mu g/mL for methanol extracts of A. viridiflora, A. glabra and A. monticola, and 256 mu g/mL for cyclohexane extracts of A. viridiflora, A. glabra and A. fissa. The best overall activity was obtained with A. monticola extracts. No significant difference was found in the ellagic acid contents of the methanol extracts of the tested Alchemilla species (0.2-0.3 mg/mL), and anti-H. pylori activity was similar (4-32 mu g/mL). Ellagic acid exhibited strong activity at very low concentrations (0.125-0.5 mu g/mL), while the second identified compound, quercetin-3-O-beta-D-glucoside, was also very active in concentration of 2-16 mu g/mL.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)", volume = "10", number = "8", pages = "1369-1371", url = "https://hdl.handle.net/21.15107/rcub_farfar_2436" }
Krivokuća, M., Niketić, M., Milenković, M., Golić, N., Masia, C., Scaltrito, M. M., Sisto, F.,& Kundaković, T.. (2015). Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae). in Natural Product Communications Natural Products Inc, Westerville., 10(8), 1369-1371. https://hdl.handle.net/21.15107/rcub_farfar_2436
Krivokuća M, Niketić M, Milenković M, Golić N, Masia C, Scaltrito MM, Sisto F, Kundaković T. Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae). in Natural Product Communications. 2015;10(8):1369-1371. https://hdl.handle.net/21.15107/rcub_farfar_2436 .
Krivokuća, Marija, Niketić, Marjan, Milenković, Marina, Golić, Nataša, Masia, Carla, Scaltrito, Maria Maddalena, Sisto, Francesca, Kundaković, Tatjana, "Anti-Helicobacter pylori Activity of Four Alchemilla Species (Rosaceae)" in Natural Product Communications, 10, no. 8 (2015):1369-1371, https://hdl.handle.net/21.15107/rcub_farfar_2436 .