Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review
Нема приказа
Аутори
Bajić, VladanPotparević, Biljana
Živković, Lada
Sudar, Emina
Zafirović, Sonja
Obradović, Milan
Isenović, Esma
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.
Кључне речи:
Amyloid aggregation inhibitors / antioxidants / beta-sheet breakers / estrogens / immunotherapeutic Abeta / neurode-generationИзвор:
Letters in Drug Design and Discovery, 2015, 12, 2, 158-164Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
Институција/група
PharmacyTY - JOUR AU - Bajić, Vladan AU - Potparević, Biljana AU - Živković, Lada AU - Sudar, Emina AU - Zafirović, Sonja AU - Obradović, Milan AU - Isenović, Esma PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2446 AB - Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics. PB - Bentham Science Publ Ltd, Sharjah T2 - Letters in Drug Design and Discovery T1 - Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review VL - 12 IS - 2 SP - 158 EP - 164 UR - https://hdl.handle.net/21.15107/rcub_vinar_398 ER -
@article{ author = "Bajić, Vladan and Potparević, Biljana and Živković, Lada and Sudar, Emina and Zafirović, Sonja and Obradović, Milan and Isenović, Esma", year = "2015", abstract = "Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Letters in Drug Design and Discovery", title = "Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review", volume = "12", number = "2", pages = "158-164", url = "https://hdl.handle.net/21.15107/rcub_vinar_398" }
Bajić, V., Potparević, B., Živković, L., Sudar, E., Zafirović, S., Obradović, M.,& Isenović, E.. (2015). Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review. in Letters in Drug Design and Discovery Bentham Science Publ Ltd, Sharjah., 12(2), 158-164. https://hdl.handle.net/21.15107/rcub_vinar_398
Bajić V, Potparević B, Živković L, Sudar E, Zafirović S, Obradović M, Isenović E. Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review. in Letters in Drug Design and Discovery. 2015;12(2):158-164. https://hdl.handle.net/21.15107/rcub_vinar_398 .
Bajić, Vladan, Potparević, Biljana, Živković, Lada, Sudar, Emina, Zafirović, Sonja, Obradović, Milan, Isenović, Esma, "Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review" in Letters in Drug Design and Discovery, 12, no. 2 (2015):158-164, https://hdl.handle.net/21.15107/rcub_vinar_398 .