Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
2015
Аутори
Savić, IvanNikolić, Vesna D.
Savić-Gajić, Ivana
Nikolić, Ljubiša
Ibrić, Svetlana
Gajić, Dragoljub G.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.
Кључне речи:
amygdalin / plum seeds / extraction / central composite design / multilayer perceptron / isolation / structural characterizationИзвор:
Frontiers in Plant Science, 2015, 6Издавач:
- Frontiers Media Sa, Lausanne
Финансирање / пројекти:
- Биљни и синтетички биоактивни производи новије генерације (RS-MESTD-Technological Development (TD or TR)-34012)
DOI: 10.3389/fpls.2015.00276
ISSN: 1664-462X
PubMed: 25972881
WoS: 000356894600001
Scopus: 2-s2.0-84934877490
Институција/група
PharmacyTY - JOUR AU - Savić, Ivan AU - Nikolić, Vesna D. AU - Savić-Gajić, Ivana AU - Nikolić, Ljubiša AU - Ibrić, Svetlana AU - Gajić, Dragoljub G. PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2471 AB - The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods. PB - Frontiers Media Sa, Lausanne T2 - Frontiers in Plant Science T1 - Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen) VL - 6 DO - 10.3389/fpls.2015.00276 ER -
@article{ author = "Savić, Ivan and Nikolić, Vesna D. and Savić-Gajić, Ivana and Nikolić, Ljubiša and Ibrić, Svetlana and Gajić, Dragoljub G.", year = "2015", abstract = "The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.", publisher = "Frontiers Media Sa, Lausanne", journal = "Frontiers in Plant Science", title = "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)", volume = "6", doi = "10.3389/fpls.2015.00276" }
Savić, I., Nikolić, V. D., Savić-Gajić, I., Nikolić, L., Ibrić, S.,& Gajić, D. G.. (2015). Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science Frontiers Media Sa, Lausanne., 6. https://doi.org/10.3389/fpls.2015.00276
Savić I, Nikolić VD, Savić-Gajić I, Nikolić L, Ibrić S, Gajić DG. Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen). in Frontiers in Plant Science. 2015;6. doi:10.3389/fpls.2015.00276 .
Savić, Ivan, Nikolić, Vesna D., Savić-Gajić, Ivana, Nikolić, Ljubiša, Ibrić, Svetlana, Gajić, Dragoljub G., "Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)" in Frontiers in Plant Science, 6 (2015), https://doi.org/10.3389/fpls.2015.00276 . .