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Effect of Benidipine in Human Internal Mammary Artery and Clinical Implications
dc.creator | Hou, Hai-Tao | |
dc.creator | Wang, Jun | |
dc.creator | Wang, Zheng-Qing | |
dc.creator | Liu, Xiao-Cheng | |
dc.creator | Marinko, Marija | |
dc.creator | Novaković, Aleksandra | |
dc.creator | Yang, Qin | |
dc.creator | He, Guo-Wei | |
dc.date.accessioned | 2019-09-02T11:50:19Z | |
dc.date.available | 2019-09-02T11:50:19Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0003-4975 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2525 | |
dc.description.abstract | Background. Graft spasm remains challenging in coronary artery bypass grafting (CABG). Calcium antagonists are commonly used in patients with coronary artery disease. This study investigated the inhibitory effect of third-generation dihydropyridine calcium channel antagonist benidipine on the vasoconstriction induced by various vasoconstrictors in the human internalmammary artery(IMA). Methods. Isolated human IMA rings (N = 65, taken from 37 patients undergoing CABG) were studied in a myograph in 2 ways: the relaxing effect of benidipine on vasoconstrictor-induced precontraction by KCl and U46619 and the depressing effect of benidipine at plasma concentrations on the contraction. Enzyme-linked immunosorbent assay (ELISA) was used to measure the change of the protein related to the L-type calcium channel. Results. Benidipine caused more relaxation in KCl-contracted (86.7% +/- 3.3%; n = 12) than in U46619-contracted (63.8% +/- 5.3%; n = 8; p lt 0.001) IMA rings. Pretreatment of IMA with plasma concentrations of benidipine (-6.92 log M) significantly depressed subsequent contraction by KCl (from 17.3 +/- 2.7 mN to 7.4 +/- 1.2 mN; n = 6; p lt 0.05) but did not significantly affect the contraction caused by U46619. Benidipine also caused a decrease of caveolin (CaV) 1.2 protein content (0.55 +/- 0.02 versus 0.63 +/- 0.02 mg/mL; p lt 0.05). Conclusions. We conclude that in human IMA, the third-generation dihydropyridine calcium channel antagonist benidipine has a potent inhibitory effect on the vasoconstriction mediated by a variety of vasoconstrictors. Use of benidipine in patients undergoing CABG may provide vasorelaxant or antispastic effects in the grafts. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.relation | Tianjin Binhai Key Platform for Creative Research Program - 2012-BH110004 | |
dc.relation | Binhai New Area Health Bureau - 2012BWKZ008 | |
dc.relation | Tianjin Health Bureau - 2013KZ009 | |
dc.relation | National Science and Technology Major Project - 2013ZX09303004-005 | |
dc.relation | Hangzhou Science and Technology Projects - 20140633B12 | |
dc.relation | Binhai New Area Health Bureau - 2014BWKY002 | |
dc.relation | Binhai New Area Health Bureau - 2014BWKY010 | |
dc.relation | Tianjin Health Bureau - 2014KZ005 | |
dc.relation | National Natural Science Foundation of China - 81170148 | |
dc.relation | Zhejiang Provincial Natural Science Foundation - LY15H020008 | |
dc.rights | restrictedAccess | |
dc.source | Annals of Thoracic Surgery | |
dc.title | Effect of Benidipine in Human Internal Mammary Artery and Clinical Implications | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Маринко, Марија; Хоу, Хаи-Тао; Wанг, Зхенг-Qинг; Wанг, Јун; Новаковић, Aлександра; Yанг, Qин; Лиу, Xиао-Цхенг; Хе, Гуо-Wеи; | |
dc.citation.volume | 101 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1789 | |
dc.citation.epage | 1795 | |
dc.citation.other | 101(5): 1789-1795 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000375868500040 | |
dc.identifier.doi | 10.1016/j.athoracsur.2015.10.029 | |
dc.identifier.pmid | 26707005 | |
dc.identifier.scopus | 2-s2.0-84963976346 | |
dc.type.version | publishedVersion |