Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults
Само за регистроване кориснике
2016
Аутори
Topić, AleksandraMalić, Živka
Francuski, Đorđe
Stanković, Marija
Marković, Bojan
Soskić, Blagoje
Tomić, Branko
Ilić, Stefan
Dobrivojević, Snežana
Drca, Sanja
Radojković, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI lt 25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.
Извор:
Biomarkers, 2016, 21, 2, 186-193Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Комплексне болести као модел систем за проучавање модулације фенотипа-структурна и функционална анализа молекуларних биомаркера (RS-MESTD-Basic Research (BR or ON)-173008)
DOI: 10.3109/1354750X.2015.1126647
ISSN: 1354-750X
PubMed: 26754535
WoS: 000373230900014
Scopus: 2-s2.0-84954304812
Институција/група
PharmacyTY - JOUR AU - Topić, Aleksandra AU - Malić, Živka AU - Francuski, Đorđe AU - Stanković, Marija AU - Marković, Bojan AU - Soskić, Blagoje AU - Tomić, Branko AU - Ilić, Stefan AU - Dobrivojević, Snežana AU - Drca, Sanja AU - Radojković, Dragica PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2600 AB - Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI lt 25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases. PB - Taylor & Francis Ltd, Abingdon T2 - Biomarkers T1 - Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults VL - 21 IS - 2 SP - 186 EP - 193 DO - 10.3109/1354750X.2015.1126647 ER -
@article{ author = "Topić, Aleksandra and Malić, Živka and Francuski, Đorđe and Stanković, Marija and Marković, Bojan and Soskić, Blagoje and Tomić, Branko and Ilić, Stefan and Dobrivojević, Snežana and Drca, Sanja and Radojković, Dragica", year = "2016", abstract = "Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI lt 25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Biomarkers", title = "Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults", volume = "21", number = "2", pages = "186-193", doi = "10.3109/1354750X.2015.1126647" }
Topić, A., Malić, Ž., Francuski, Đ., Stanković, M., Marković, B., Soskić, B., Tomić, B., Ilić, S., Dobrivojević, S., Drca, S.,& Radojković, D.. (2016). Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults. in Biomarkers Taylor & Francis Ltd, Abingdon., 21(2), 186-193. https://doi.org/10.3109/1354750X.2015.1126647
Topić A, Malić Ž, Francuski Đ, Stanković M, Marković B, Soskić B, Tomić B, Ilić S, Dobrivojević S, Drca S, Radojković D. Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults. in Biomarkers. 2016;21(2):186-193. doi:10.3109/1354750X.2015.1126647 .
Topić, Aleksandra, Malić, Živka, Francuski, Đorđe, Stanković, Marija, Marković, Bojan, Soskić, Blagoje, Tomić, Branko, Ilić, Stefan, Dobrivojević, Snežana, Drca, Sanja, Radojković, Dragica, "Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults" in Biomarkers, 21, no. 2 (2016):186-193, https://doi.org/10.3109/1354750X.2015.1126647 . .