Exercise capacity is not impaired after acute alcohol ingestion: a pilot study
Само за регистроване кориснике
2016
Аутори
Popović, DejanaDamjanović, Svetozar S.
Plećaš-Solarović, Bosiljka
Pešić, Vesna
Stojiljković, Stanimir
Banović, Marko
Ristić, Arsen
Mantegazza, Valentina
Agostoni, Piergiuseppe
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly... increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism.
Извор:
Journal of Cardiovascular Medicine, 2016, 17, 12, 896-901Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Faculty of Pharmacy University of Belgrade
DOI: 10.2459/JCM.0000000000000151
ISSN: 1558-2027
PubMed: 25083719
WoS: 000387271400009
Scopus: 2-s2.0-84905299128
Институција/група
PharmacyTY - JOUR AU - Popović, Dejana AU - Damjanović, Svetozar S. AU - Plećaš-Solarović, Bosiljka AU - Pešić, Vesna AU - Stojiljković, Stanimir AU - Banović, Marko AU - Ristić, Arsen AU - Mantegazza, Valentina AU - Agostoni, Piergiuseppe PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2619 AB - The usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Journal of Cardiovascular Medicine T1 - Exercise capacity is not impaired after acute alcohol ingestion: a pilot study VL - 17 IS - 12 SP - 896 EP - 901 DO - 10.2459/JCM.0000000000000151 ER -
@article{ author = "Popović, Dejana and Damjanović, Svetozar S. and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Stojiljković, Stanimir and Banović, Marko and Ristić, Arsen and Mantegazza, Valentina and Agostoni, Piergiuseppe", year = "2016", abstract = "The usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Journal of Cardiovascular Medicine", title = "Exercise capacity is not impaired after acute alcohol ingestion: a pilot study", volume = "17", number = "12", pages = "896-901", doi = "10.2459/JCM.0000000000000151" }
Popović, D., Damjanović, S. S., Plećaš-Solarović, B., Pešić, V., Stojiljković, S., Banović, M., Ristić, A., Mantegazza, V.,& Agostoni, P.. (2016). Exercise capacity is not impaired after acute alcohol ingestion: a pilot study. in Journal of Cardiovascular Medicine Lippincott Williams & Wilkins, Philadelphia., 17(12), 896-901. https://doi.org/10.2459/JCM.0000000000000151
Popović D, Damjanović SS, Plećaš-Solarović B, Pešić V, Stojiljković S, Banović M, Ristić A, Mantegazza V, Agostoni P. Exercise capacity is not impaired after acute alcohol ingestion: a pilot study. in Journal of Cardiovascular Medicine. 2016;17(12):896-901. doi:10.2459/JCM.0000000000000151 .
Popović, Dejana, Damjanović, Svetozar S., Plećaš-Solarović, Bosiljka, Pešić, Vesna, Stojiljković, Stanimir, Banović, Marko, Ristić, Arsen, Mantegazza, Valentina, Agostoni, Piergiuseppe, "Exercise capacity is not impaired after acute alcohol ingestion: a pilot study" in Journal of Cardiovascular Medicine, 17, no. 12 (2016):896-901, https://doi.org/10.2459/JCM.0000000000000151 . .