Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls
2016
Authors
Klisić, AleksandraKavarić, Nebojša
Soldatović, Ivan
Bjelaković, Bojko
Kotur-Stevuljević, Jelena
Article (Published version)
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Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex..., HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.
Source:
Journal of Medical Biochemistry, 2016, 35, 3, 282-292Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1515/jomb-2016-0005
ISSN: 1452-8258
PubMed: 28356879
WoS: 000379520000002
Scopus: 2-s2.0-84978857977
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PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kavarić, Nebojša AU - Soldatović, Ivan AU - Bjelaković, Bojko AU - Kotur-Stevuljević, Jelena PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2661 AB - Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls VL - 35 IS - 3 SP - 282 EP - 292 DO - 10.1515/jomb-2016-0005 ER -
@article{ author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Bjelaković, Bojko and Kotur-Stevuljević, Jelena", year = "2016", abstract = "Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls", volume = "35", number = "3", pages = "282-292", doi = "10.1515/jomb-2016-0005" }
Klisić, A., Kavarić, N., Soldatović, I., Bjelaković, B.,& Kotur-Stevuljević, J.. (2016). Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(3), 282-292. https://doi.org/10.1515/jomb-2016-0005
Klisić A, Kavarić N, Soldatović I, Bjelaković B, Kotur-Stevuljević J. Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry. 2016;35(3):282-292. doi:10.1515/jomb-2016-0005 .
Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Bjelaković, Bojko, Kotur-Stevuljević, Jelena, "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls" in Journal of Medical Biochemistry, 35, no. 3 (2016):282-292, https://doi.org/10.1515/jomb-2016-0005 . .