Radioisotopes used as radiotracers for in vitro and in vivo diagnostics
Abstract
Many of modern diagnostic methods cannot be achieved without radioisotopes. In this review, an overview of the most common radioisotopes (radionuclides) used as markers for in vitro and in vivo studies is provided. To determine the extremely low concentrations of some biological molecules (hormones, drugs, toxins, nucleic acid, etc.) in biological fluids for in vitro studies, β and/or γ emitters with different half-lives: H-3, C-14, P-32, P-33, I-125, Cr-51 were frequently used. The majority of all radionuclides (90 %) were utilized for in vivo diagnostics. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are imaging modalities widely used in diagnostic nuclear medicine. The most important diagnostic radionuclides are technetium-99m (for single photon emission computed tomography) and fluorine-18 (for positron emission tomography).
Keywords:
Positron emission tomography / Radionuclides / Radiotracers / Single photon emission computed tomography / Technetium-99mSource:
Asian Journal of Chemistry, 2016, 28, 2, 235-241Publisher:
- Chemical Publishing Co.
Collections
Institution/Community
PharmacyTY - JOUR AU - Kuntić, Vesna AU - Brborić, Jasmina AU - Vujić, Zorica AU - Uskoković-Marković, Snežana PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2718 AB - Many of modern diagnostic methods cannot be achieved without radioisotopes. In this review, an overview of the most common radioisotopes (radionuclides) used as markers for in vitro and in vivo studies is provided. To determine the extremely low concentrations of some biological molecules (hormones, drugs, toxins, nucleic acid, etc.) in biological fluids for in vitro studies, β and/or γ emitters with different half-lives: H-3, C-14, P-32, P-33, I-125, Cr-51 were frequently used. The majority of all radionuclides (90 %) were utilized for in vivo diagnostics. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are imaging modalities widely used in diagnostic nuclear medicine. The most important diagnostic radionuclides are technetium-99m (for single photon emission computed tomography) and fluorine-18 (for positron emission tomography). PB - Chemical Publishing Co. T2 - Asian Journal of Chemistry T1 - Radioisotopes used as radiotracers for in vitro and in vivo diagnostics VL - 28 IS - 2 SP - 235 EP - 241 DO - 10.14233/ajchem.2016.19401 ER -
@article{ author = "Kuntić, Vesna and Brborić, Jasmina and Vujić, Zorica and Uskoković-Marković, Snežana", year = "2016", abstract = "Many of modern diagnostic methods cannot be achieved without radioisotopes. In this review, an overview of the most common radioisotopes (radionuclides) used as markers for in vitro and in vivo studies is provided. To determine the extremely low concentrations of some biological molecules (hormones, drugs, toxins, nucleic acid, etc.) in biological fluids for in vitro studies, β and/or γ emitters with different half-lives: H-3, C-14, P-32, P-33, I-125, Cr-51 were frequently used. The majority of all radionuclides (90 %) were utilized for in vivo diagnostics. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) are imaging modalities widely used in diagnostic nuclear medicine. The most important diagnostic radionuclides are technetium-99m (for single photon emission computed tomography) and fluorine-18 (for positron emission tomography).", publisher = "Chemical Publishing Co.", journal = "Asian Journal of Chemistry", title = "Radioisotopes used as radiotracers for in vitro and in vivo diagnostics", volume = "28", number = "2", pages = "235-241", doi = "10.14233/ajchem.2016.19401" }
Kuntić, V., Brborić, J., Vujić, Z.,& Uskoković-Marković, S.. (2016). Radioisotopes used as radiotracers for in vitro and in vivo diagnostics. in Asian Journal of Chemistry Chemical Publishing Co.., 28(2), 235-241. https://doi.org/10.14233/ajchem.2016.19401
Kuntić V, Brborić J, Vujić Z, Uskoković-Marković S. Radioisotopes used as radiotracers for in vitro and in vivo diagnostics. in Asian Journal of Chemistry. 2016;28(2):235-241. doi:10.14233/ajchem.2016.19401 .
Kuntić, Vesna, Brborić, Jasmina, Vujić, Zorica, Uskoković-Marković, Snežana, "Radioisotopes used as radiotracers for in vitro and in vivo diagnostics" in Asian Journal of Chemistry, 28, no. 2 (2016):235-241, https://doi.org/10.14233/ajchem.2016.19401 . .