Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea
Само за регистроване кориснике
2016
Аутори
Vekić, JelenaJoppa, Pavol
Habalova, Viera
Tisko, Radovan
Zeljković, Aleksandra
Pobeha, Pavol
Gojković, Tamara
Spasojević-Kalimanovska, Vesna
Strbova, Zuzana
Kuklisova, Zuzana
Slaba, Eva
Rizzo, Manfredi
Tkacova, Ruzena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syn...drome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.
Извор:
Angiology, 2016, 67, 10, 937-944Издавач:
- Sage Publications Inc, Thousand Oaks
Финансирање / пројекти:
- Slovak Research and Development Agency of the Ministry of Education, Slovakia - VEGA 1/0863/15
DOI: 10.1177/0003319716636512
ISSN: 0003-3197
PubMed: 26941371
WoS: 000386036600009
Scopus: 2-s2.0-84990852858
Институција/група
PharmacyTY - JOUR AU - Vekić, Jelena AU - Joppa, Pavol AU - Habalova, Viera AU - Tisko, Radovan AU - Zeljković, Aleksandra AU - Pobeha, Pavol AU - Gojković, Tamara AU - Spasojević-Kalimanovska, Vesna AU - Strbova, Zuzana AU - Kuklisova, Zuzana AU - Slaba, Eva AU - Rizzo, Manfredi AU - Tkacova, Ruzena PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2765 AB - Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea VL - 67 IS - 10 SP - 937 EP - 944 DO - 10.1177/0003319716636512 ER -
@article{ author = "Vekić, Jelena and Joppa, Pavol and Habalova, Viera and Tisko, Radovan and Zeljković, Aleksandra and Pobeha, Pavol and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Strbova, Zuzana and Kuklisova, Zuzana and Slaba, Eva and Rizzo, Manfredi and Tkacova, Ruzena", year = "2016", abstract = "Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea", volume = "67", number = "10", pages = "937-944", doi = "10.1177/0003319716636512" }
Vekić, J., Joppa, P., Habalova, V., Tisko, R., Zeljković, A., Pobeha, P., Gojković, T., Spasojević-Kalimanovska, V., Strbova, Z., Kuklisova, Z., Slaba, E., Rizzo, M.,& Tkacova, R.. (2016). Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology Sage Publications Inc, Thousand Oaks., 67(10), 937-944. https://doi.org/10.1177/0003319716636512
Vekić J, Joppa P, Habalova V, Tisko R, Zeljković A, Pobeha P, Gojković T, Spasojević-Kalimanovska V, Strbova Z, Kuklisova Z, Slaba E, Rizzo M, Tkacova R. Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology. 2016;67(10):937-944. doi:10.1177/0003319716636512 .
Vekić, Jelena, Joppa, Pavol, Habalova, Viera, Tisko, Radovan, Zeljković, Aleksandra, Pobeha, Pavol, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Strbova, Zuzana, Kuklisova, Zuzana, Slaba, Eva, Rizzo, Manfredi, Tkacova, Ruzena, "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea" in Angiology, 67, no. 10 (2016):937-944, https://doi.org/10.1177/0003319716636512 . .