Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study
Abstract
In the last 2 decades, numerous studies have been carried out to synthesize biodegradable and nontoxic micro- and nanoparticulate carriers for nonsteroidal anti-inflammatory drugs. The potential benefits of these carriers are reduction of dosing frequency and minimization of side effects due to prolonged/delayed drug release, increased selectivity for target tissues and possibility of direct administration to the site of action.This chapter discusses characteristics of alginate-based micro- and nanoparticles reinforced with chitosan and gives an overview of the techniques commonly used for preparation of these drug carriers. It is focused on the chitosans' functionality-related characteristics, such as molecular weight and viscosity, and their influence on feasibility of the alginate-chitosan particulate carriers for oral delivery of nonsteroidal anti-inflammatory drugs. Additionally, chitosan's structure, safety, and overall characteristics are discussed in detail for better understan...ding.
Keywords:
Alginate / Chitosan / Chitosan's functionality / Microparticles / Nanoparticles / Nonsteroidal anti-inflammatory drugsSource:
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a, 2017, 133-160Publisher:
- Elsevier Inc.
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-MESTD-Technological Development (TD or TR)-34031)
Collections
Institution/Community
PharmacyTY - CHAP AU - Čalija, Bojan AU - Cekić, Nebojša AU - Milić, Jela PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2789 AB - In the last 2 decades, numerous studies have been carried out to synthesize biodegradable and nontoxic micro- and nanoparticulate carriers for nonsteroidal anti-inflammatory drugs. The potential benefits of these carriers are reduction of dosing frequency and minimization of side effects due to prolonged/delayed drug release, increased selectivity for target tissues and possibility of direct administration to the site of action.This chapter discusses characteristics of alginate-based micro- and nanoparticles reinforced with chitosan and gives an overview of the techniques commonly used for preparation of these drug carriers. It is focused on the chitosans' functionality-related characteristics, such as molecular weight and viscosity, and their influence on feasibility of the alginate-chitosan particulate carriers for oral delivery of nonsteroidal anti-inflammatory drugs. Additionally, chitosan's structure, safety, and overall characteristics are discussed in detail for better understanding. PB - Elsevier Inc. T2 - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a T1 - Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study SP - 133 EP - 160 DO - 10.1016/B978-0-12-804017-1.00005-4 ER -
@inbook{ author = "Čalija, Bojan and Cekić, Nebojša and Milić, Jela", year = "2017", abstract = "In the last 2 decades, numerous studies have been carried out to synthesize biodegradable and nontoxic micro- and nanoparticulate carriers for nonsteroidal anti-inflammatory drugs. The potential benefits of these carriers are reduction of dosing frequency and minimization of side effects due to prolonged/delayed drug release, increased selectivity for target tissues and possibility of direct administration to the site of action.This chapter discusses characteristics of alginate-based micro- and nanoparticles reinforced with chitosan and gives an overview of the techniques commonly used for preparation of these drug carriers. It is focused on the chitosans' functionality-related characteristics, such as molecular weight and viscosity, and their influence on feasibility of the alginate-chitosan particulate carriers for oral delivery of nonsteroidal anti-inflammatory drugs. Additionally, chitosan's structure, safety, and overall characteristics are discussed in detail for better understanding.", publisher = "Elsevier Inc.", journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a", booktitle = "Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study", pages = "133-160", doi = "10.1016/B978-0-12-804017-1.00005-4" }
Čalija, B., Cekić, N.,& Milić, J.. (2017). Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a Elsevier Inc.., 133-160. https://doi.org/10.1016/B978-0-12-804017-1.00005-4
Čalija B, Cekić N, Milić J. Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:133-160. doi:10.1016/B978-0-12-804017-1.00005-4 .
Čalija, Bojan, Cekić, Nebojša, Milić, Jela, "Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):133-160, https://doi.org/10.1016/B978-0-12-804017-1.00005-4 . .