Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome
Само за регистроване кориснике
2017
Аутори
Popović, DejanaDamjanović, Svetozar S.
Đorđević, Tea
Martić, Dejana
Ignjatović, Svetlana
Milinković, Neda
Banović, Marko
Lasica, Ratko
Petrović, Milan
Guazzi, Marco
Arena, Ross
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects wer...e subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.
Извор:
Supportive Care in Cancer, 2017, 20, 5, 523-531Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Акутни коронарни синдром: истраживање вулнерабилности (плака, крви и миокарда), оптимално лечење и одређивање прогностичких фактора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
DOI: 10.1080/10253890.2017.1368488
ISSN: 1025-3890
PubMed: 28845719
WoS: 000418047600009
Scopus: 2-s2.0-85028541384
Институција/група
PharmacyTY - JOUR AU - Popović, Dejana AU - Damjanović, Svetozar S. AU - Đorđević, Tea AU - Martić, Dejana AU - Ignjatović, Svetlana AU - Milinković, Neda AU - Banović, Marko AU - Lasica, Ratko AU - Petrović, Milan AU - Guazzi, Marco AU - Arena, Ross PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2861 AB - Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events. PB - Taylor & Francis Ltd, Abingdon T2 - Supportive Care in Cancer T1 - Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome VL - 20 IS - 5 SP - 523 EP - 531 DO - 10.1080/10253890.2017.1368488 ER -
@article{ author = "Popović, Dejana and Damjanović, Svetozar S. and Đorđević, Tea and Martić, Dejana and Ignjatović, Svetlana and Milinković, Neda and Banović, Marko and Lasica, Ratko and Petrović, Milan and Guazzi, Marco and Arena, Ross", year = "2017", abstract = "Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Supportive Care in Cancer", title = "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome", volume = "20", number = "5", pages = "523-531", doi = "10.1080/10253890.2017.1368488" }
Popović, D., Damjanović, S. S., Đorđević, T., Martić, D., Ignjatović, S., Milinković, N., Banović, M., Lasica, R., Petrović, M., Guazzi, M.,& Arena, R.. (2017). Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer Taylor & Francis Ltd, Abingdon., 20(5), 523-531. https://doi.org/10.1080/10253890.2017.1368488
Popović D, Damjanović SS, Đorđević T, Martić D, Ignjatović S, Milinković N, Banović M, Lasica R, Petrović M, Guazzi M, Arena R. Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer. 2017;20(5):523-531. doi:10.1080/10253890.2017.1368488 .
Popović, Dejana, Damjanović, Svetozar S., Đorđević, Tea, Martić, Dejana, Ignjatović, Svetlana, Milinković, Neda, Banović, Marko, Lasica, Ratko, Petrović, Milan, Guazzi, Marco, Arena, Ross, "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome" in Supportive Care in Cancer, 20, no. 5 (2017):523-531, https://doi.org/10.1080/10253890.2017.1368488 . .