Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome
Само за регистроване кориснике
2017
Аутори
Popović, DejanaMartić, Dejana
Đorđević, Tea
Pešić, Vesna
Guazzi, Marco
Myers, Jonathan
Mohebi, Reza
Arena, Ross
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide ou...tput (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p lt 0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.
Кључне речи:
Cardiopulmonary exercise test / Coronary artery disease / Carbon-dioxide / Oxygen uptake / RecoveryИзвор:
International Journal of Cardiology, 2017, 248, 39-45Издавач:
- Elsevier Ireland Ltd, Clare
Финансирање / пројекти:
- Акутни коронарни синдром: истраживање вулнерабилности (плака, крви и миокарда), оптимално лечење и одређивање прогностичких фактора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
DOI: 10.1016/j.ijcard.2017.06.107
ISSN: 0167-5273
PubMed: 28689985
WoS: 000411439900007
Scopus: 2-s2.0-85021854467
Институција/група
PharmacyTY - JOUR AU - Popović, Dejana AU - Martić, Dejana AU - Đorđević, Tea AU - Pešić, Vesna AU - Guazzi, Marco AU - Myers, Jonathan AU - Mohebi, Reza AU - Arena, Ross PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2877 AB - Background: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p lt 0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis. PB - Elsevier Ireland Ltd, Clare T2 - International Journal of Cardiology T1 - Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome VL - 248 SP - 39 EP - 45 DO - 10.1016/j.ijcard.2017.06.107 ER -
@article{ author = "Popović, Dejana and Martić, Dejana and Đorđević, Tea and Pešić, Vesna and Guazzi, Marco and Myers, Jonathan and Mohebi, Reza and Arena, Ross", year = "2017", abstract = "Background: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p lt 0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.", publisher = "Elsevier Ireland Ltd, Clare", journal = "International Journal of Cardiology", title = "Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome", volume = "248", pages = "39-45", doi = "10.1016/j.ijcard.2017.06.107" }
Popović, D., Martić, D., Đorđević, T., Pešić, V., Guazzi, M., Myers, J., Mohebi, R.,& Arena, R.. (2017). Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome. in International Journal of Cardiology Elsevier Ireland Ltd, Clare., 248, 39-45. https://doi.org/10.1016/j.ijcard.2017.06.107
Popović D, Martić D, Đorđević T, Pešić V, Guazzi M, Myers J, Mohebi R, Arena R. Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome. in International Journal of Cardiology. 2017;248:39-45. doi:10.1016/j.ijcard.2017.06.107 .
Popović, Dejana, Martić, Dejana, Đorđević, Tea, Pešić, Vesna, Guazzi, Marco, Myers, Jonathan, Mohebi, Reza, Arena, Ross, "Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome" in International Journal of Cardiology, 248 (2017):39-45, https://doi.org/10.1016/j.ijcard.2017.06.107 . .