Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula
2017
Authors
Milić, JelaRadojković, Branko
Jančić-Stojanović, Biljana
Drašković, Jasmina
Mirašević, Slavica
Čalija, Bojan
Article (Published version)
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In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C).
U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).
Keywords:
omeprazole / stability / pediatric suspension / liquid chromatography / omeprazol / stabilnost / suspenzija za pedijatrijsku primenu / tečna hromatografijaSource:
Arhiv za farmaciju, 2017, 67, 1, 14-25Publisher:
- Savez farmaceutskih udruženja Srbije, Beograd
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PharmacyTY - JOUR AU - Milić, Jela AU - Radojković, Branko AU - Jančić-Stojanović, Biljana AU - Drašković, Jasmina AU - Mirašević, Slavica AU - Čalija, Bojan PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2943 AB - In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C). AB - U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C). PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules T1 - Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula VL - 67 IS - 1 SP - 14 EP - 25 DO - 10.5937/arhfarm1701014M ER -
@article{ author = "Milić, Jela and Radojković, Branko and Jančić-Stojanović, Biljana and Drašković, Jasmina and Mirašević, Slavica and Čalija, Bojan", year = "2017", abstract = "In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C)., U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules, Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula", volume = "67", number = "1", pages = "14-25", doi = "10.5937/arhfarm1701014M" }
Milić, J., Radojković, B., Jančić-Stojanović, B., Drašković, J., Mirašević, S.,& Čalija, B.. (2017). Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 67(1), 14-25. https://doi.org/10.5937/arhfarm1701014M
Milić J, Radojković B, Jančić-Stojanović B, Drašković J, Mirašević S, Čalija B. Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju. 2017;67(1):14-25. doi:10.5937/arhfarm1701014M .
Milić, Jela, Radojković, Branko, Jančić-Stojanović, Biljana, Drašković, Jasmina, Mirašević, Slavica, Čalija, Bojan, "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules" in Arhiv za farmaciju, 67, no. 1 (2017):14-25, https://doi.org/10.5937/arhfarm1701014M . .
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