Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease
2017
Authors
Ristovski-Kornić, DanijelaStefanović, Aleksandra
Kotur-Stevuljević, Jelena
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Miljković, Milica
Paripović, Dušan
Peco-Antić, Amira
Jelić-Ivanović, Zorana
Article (Published version)
Metadata
Show full item recordAbstract
Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p lt 0.001), as well as the atherogenic index of plasma (p lt 0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently a...ssociated with increased AIP in the patient group (p lt 0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.
Source:
Journal of Medical Biochemistry, 2017, 36, 1, 23-31Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1515/jomb-2016-0027
ISSN: 1452-8258
PubMed: 28680346
WoS: 000393585400004
Scopus: 2-s2.0-85011304718
Collections
Institution/Community
PharmacyTY - JOUR AU - Ristovski-Kornić, Danijela AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Zeljković, Aleksandra AU - Spasojević-Kalimanovska, Vesna AU - Vekić, Jelena AU - Miljković, Milica AU - Paripović, Dušan AU - Peco-Antić, Amira AU - Jelić-Ivanović, Zorana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2956 AB - Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p lt 0.001), as well as the atherogenic index of plasma (p lt 0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p lt 0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease VL - 36 IS - 1 SP - 23 EP - 31 DO - 10.1515/jomb-2016-0027 ER -
@article{ author = "Ristovski-Kornić, Danijela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Zeljković, Aleksandra and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Miljković, Milica and Paripović, Dušan and Peco-Antić, Amira and Jelić-Ivanović, Zorana", year = "2017", abstract = "Background: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. Methods: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex. The Atherogenic Index of Plasma (AIP) was calculated according to the appropriate equation. Results: We did not find any significant differences in myeloperoxidase concentrations between the investigated groups (p = 0.394). Oxidative stress parameters were, however, significantly higher in the patient group (p lt 0.001), as well as the atherogenic index of plasma (p lt 0.001). Myelo per oxidase concentration and advanced oxidation protein product (AOPP) concentration were independently associated with increased AIP in the patient group (p lt 0.05). Conclusions: Changes in AIP in children with ERSD are associated with the oxidative stress status and myeloper oxidase concentration.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease", volume = "36", number = "1", pages = "23-31", doi = "10.1515/jomb-2016-0027" }
Ristovski-Kornić, D., Stefanović, A., Kotur-Stevuljević, J., Zeljković, A., Spasojević-Kalimanovska, V., Vekić, J., Miljković, M., Paripović, D., Peco-Antić, A.,& Jelić-Ivanović, Z.. (2017). Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(1), 23-31. https://doi.org/10.1515/jomb-2016-0027
Ristovski-Kornić D, Stefanović A, Kotur-Stevuljević J, Zeljković A, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco-Antić A, Jelić-Ivanović Z. Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease. in Journal of Medical Biochemistry. 2017;36(1):23-31. doi:10.1515/jomb-2016-0027 .
Ristovski-Kornić, Danijela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Miljković, Milica, Paripović, Dušan, Peco-Antić, Amira, Jelić-Ivanović, Zorana, "Association of Myeloperoxidase and the Atherogenic Index of Plasma in Children with End-Stage Renal Disease" in Journal of Medical Biochemistry, 36, no. 1 (2017):23-31, https://doi.org/10.1515/jomb-2016-0027 . .