Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes
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2017
Authors
Đurić, AnaBegić, Aida
Gobeljić, Borko
Pantelić, Ana
Zebić, Goran
Stevanović, Ivana
Đurđević, Dragan
Ninković, Milica
Prokić, Vera
Stanojević, Ivan
Vojvodić, Danilo
Đukić, Mirjana
Article (Published version)
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The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed ...in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes.
Keywords:
Alcohol / Disulfiram / Testicular toxicity / Oxidative stress / Transition metalsSource:
Food and Chemical Toxicology, 2017, 105, 44-51Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41018)
DOI: 10.1016/j.fct.2017.03.041
ISSN: 0278-6915
PubMed: 28344087
WoS: 000403625000006
Scopus: 2-s2.0-85016426201
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Institution/Community
PharmacyTY - JOUR AU - Đurić, Ana AU - Begić, Aida AU - Gobeljić, Borko AU - Pantelić, Ana AU - Zebić, Goran AU - Stevanović, Ivana AU - Đurđević, Dragan AU - Ninković, Milica AU - Prokić, Vera AU - Stanojević, Ivan AU - Vojvodić, Danilo AU - Đukić, Mirjana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2969 AB - The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Food and Chemical Toxicology T1 - Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes VL - 105 SP - 44 EP - 51 DO - 10.1016/j.fct.2017.03.041 ER -
@article{ author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Pantelić, Ana and Zebić, Goran and Stevanović, Ivana and Đurđević, Dragan and Ninković, Milica and Prokić, Vera and Stanojević, Ivan and Vojvodić, Danilo and Đukić, Mirjana", year = "2017", abstract = "The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Food and Chemical Toxicology", title = "Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes", volume = "105", pages = "44-51", doi = "10.1016/j.fct.2017.03.041" }
Đurić, A., Begić, A., Gobeljić, B., Pantelić, A., Zebić, G., Stevanović, I., Đurđević, D., Ninković, M., Prokić, V., Stanojević, I., Vojvodić, D.,& Đukić, M.. (2017). Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes. in Food and Chemical Toxicology Pergamon-Elsevier Science Ltd, Oxford., 105, 44-51. https://doi.org/10.1016/j.fct.2017.03.041
Đurić A, Begić A, Gobeljić B, Pantelić A, Zebić G, Stevanović I, Đurđević D, Ninković M, Prokić V, Stanojević I, Vojvodić D, Đukić M. Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes. in Food and Chemical Toxicology. 2017;105:44-51. doi:10.1016/j.fct.2017.03.041 .
Đurić, Ana, Begić, Aida, Gobeljić, Borko, Pantelić, Ana, Zebić, Goran, Stevanović, Ivana, Đurđević, Dragan, Ninković, Milica, Prokić, Vera, Stanojević, Ivan, Vojvodić, Danilo, Đukić, Mirjana, "Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes" in Food and Chemical Toxicology, 105 (2017):44-51, https://doi.org/10.1016/j.fct.2017.03.041 . .