Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements
Samo za registrovane korisnike
2017
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate t...he need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.
Ključne reči:
Folic acid / Dietary supplements / Composition / Dissolution / Disintegration / Hardness / Dosage forms / Food analysis / Food compositionIzvor:
Journal of Food Composition and Analysis, 2017, 60, 17-24Izdavač:
- Academic Press Inc Elsevier Science, San Diego
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1016/j.jfca.2017.03.005
ISSN: 0889-1575
WoS: 000402356800003
Scopus: 2-s2.0-85017184944
Institucija/grupa
PharmacyTY - JOUR AU - Đuriš, Jelena AU - Čalija, Bojan AU - Vidović, Bojana AU - Dobričić, Vladimir AU - Milić, Jela AU - Ibrić, Svetlana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3010 AB - Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements. PB - Academic Press Inc Elsevier Science, San Diego T2 - Journal of Food Composition and Analysis T1 - Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements VL - 60 SP - 17 EP - 24 DO - 10.1016/j.jfca.2017.03.005 ER -
@article{ author = "Đuriš, Jelena and Čalija, Bojan and Vidović, Bojana and Dobričić, Vladimir and Milić, Jela and Ibrić, Svetlana", year = "2017", abstract = "Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Journal of Food Composition and Analysis", title = "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements", volume = "60", pages = "17-24", doi = "10.1016/j.jfca.2017.03.005" }
Đuriš, J., Čalija, B., Vidović, B., Dobričić, V., Milić, J.,& Ibrić, S.. (2017). Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis Academic Press Inc Elsevier Science, San Diego., 60, 17-24. https://doi.org/10.1016/j.jfca.2017.03.005
Đuriš J, Čalija B, Vidović B, Dobričić V, Milić J, Ibrić S. Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis. 2017;60:17-24. doi:10.1016/j.jfca.2017.03.005 .
Đuriš, Jelena, Čalija, Bojan, Vidović, Bojana, Dobričić, Vladimir, Milić, Jela, Ibrić, Svetlana, "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements" in Journal of Food Composition and Analysis, 60 (2017):17-24, https://doi.org/10.1016/j.jfca.2017.03.005 . .