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Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)
dc.creator | Suručić, Relja V. | |
dc.creator | Kundaković, Tatjana | |
dc.creator | Lakušić, Branislava | |
dc.creator | Drakul, Dragana | |
dc.creator | Milovanović, Slobodan R. | |
dc.creator | Kovačević, Nada | |
dc.date.accessioned | 2019-09-02T12:02:59Z | |
dc.date.available | 2019-09-02T12:02:59Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3027 | |
dc.description.abstract | The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension. | en |
dc.publisher | Wiley-VCH Verlag GMBH, Weinheim | |
dc.relation | Ministry of Science and Technology of Republic of Srpska - 19/6-020/961-110/14 | |
dc.rights | restrictedAccess | |
dc.source | Chemistry & Biodiversity | |
dc.title | Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae) | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ковачевић, Нада; Дракул, Драгана; Миловановић, Слободан Р.; Суручић, Реља В.; Лакушић, Бранислава; Кундаковић, Татјана; | |
dc.citation.volume | 14 | |
dc.citation.issue | 5 | |
dc.citation.other | 14(5): - | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000401239300004 | |
dc.identifier.doi | 10.1002/cbdv.201600407 | |
dc.identifier.pmid | 27943628 | |
dc.identifier.scopus | 2-s2.0-85017536066 | |
dc.type.version | publishedVersion |