Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
Samo za registrovane korisnike
2020
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were ev...ident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.
Ključne reči:
Inflammation / Obesity / Oxidative stress / Xanthine oxidaseIzvor:
Eating and Weight Disorders, 2020, 25, 1, 9-15Izdavač:
- Springer International Publishing
Finansiranje / projekti:
- Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1007/s40519-018-0490-5
ISSN: 1124-4909
WoS: 000511913200002
Scopus: 2-s2.0-85042382753
Institucija/grupa
PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kocić, Gordana AU - Kavarić, Nebojša AU - Jovanović, M AU - Stanišić, Verica AU - Ninić, Ana PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3142 AB - Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study. PB - Springer International Publishing T2 - Eating and Weight Disorders T1 - Body mass index is independently associated with xanthine oxidase activity in overweight/obese population VL - 25 IS - 1 SP - 9 EP - 15 DO - 10.1007/s40519-018-0490-5 ER -
@article{ author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, M and Stanišić, Verica and Ninić, Ana", year = "2020", abstract = "Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.", publisher = "Springer International Publishing", journal = "Eating and Weight Disorders", title = "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population", volume = "25", number = "1", pages = "9-15", doi = "10.1007/s40519-018-0490-5" }
Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2020). Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders Springer International Publishing., 25(1), 9-15. https://doi.org/10.1007/s40519-018-0490-5
Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders. 2020;25(1):9-15. doi:10.1007/s40519-018-0490-5 .
Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, M, Stanišić, Verica, Ninić, Ana, "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population" in Eating and Weight Disorders, 25, no. 1 (2020):9-15, https://doi.org/10.1007/s40519-018-0490-5 . .