A perspective on multi-target drug discovery and design for complex diseases
2018
Authors
Ramsay, Rona R.Popović-Nikolić, Marija
Nikolić, Katarina
Uliassi, Elisa
Bolognesi, Maria Laura
Article (Published version)
Metadata
Show full item recordAbstract
Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.
Keywords:
Multi-target drugs / Neurodegeneration / Cancer / Cheminformatics / Virtual screening / Biological assaysSource:
Clinical and Translational Medicine, 2018, 7Publisher:
- Springeropen, London
Funding / projects:
- Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-MESTD-Basic Research (BR or ON)-172033)
DOI: 10.1186/s40169-017-0181-2
ISSN: 2001-1326
PubMed: 29340951
WoS: 000423130500001
[ Google Scholar ]Collections
Institution/Community
PharmacyTY - JOUR AU - Ramsay, Rona R. AU - Popović-Nikolić, Marija AU - Nikolić, Katarina AU - Uliassi, Elisa AU - Bolognesi, Maria Laura PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3148 AB - Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists. PB - Springeropen, London T2 - Clinical and Translational Medicine T1 - A perspective on multi-target drug discovery and design for complex diseases VL - 7 DO - 10.1186/s40169-017-0181-2 ER -
@article{ author = "Ramsay, Rona R. and Popović-Nikolić, Marija and Nikolić, Katarina and Uliassi, Elisa and Bolognesi, Maria Laura", year = "2018", abstract = "Diseases of infection, of neurodegeneration (such as Alzheimer's and Parkinson's diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.", publisher = "Springeropen, London", journal = "Clinical and Translational Medicine", title = "A perspective on multi-target drug discovery and design for complex diseases", volume = "7", doi = "10.1186/s40169-017-0181-2" }
Ramsay, R. R., Popović-Nikolić, M., Nikolić, K., Uliassi, E.,& Bolognesi, M. L.. (2018). A perspective on multi-target drug discovery and design for complex diseases. in Clinical and Translational Medicine Springeropen, London., 7. https://doi.org/10.1186/s40169-017-0181-2
Ramsay RR, Popović-Nikolić M, Nikolić K, Uliassi E, Bolognesi ML. A perspective on multi-target drug discovery and design for complex diseases. in Clinical and Translational Medicine. 2018;7. doi:10.1186/s40169-017-0181-2 .
Ramsay, Rona R., Popović-Nikolić, Marija, Nikolić, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura, "A perspective on multi-target drug discovery and design for complex diseases" in Clinical and Translational Medicine, 7 (2018), https://doi.org/10.1186/s40169-017-0181-2 . .