The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration
Abstract
Purpose: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD. In addition, the aim was to examine the gender differences and calculate the cutoff points of tested parameters that could be associated with AMD.Material and methods: A cross-sectional st...udy included 55 AMD patients aged 71.77.36 years and 65 aged-matched control subjects aged 70.256.46years.Results: Significantly lower ferritin (P=0.025), SOD (P=0.026), GPx (P=0.019), and TAS (P lt 0.004) values were found in patients with AMD compared to the controls (P lt 0.05). Significant association of GPx lt 27U/gHb (odds ratio [OR]: 1.13; 95% confidence interval [CI] 0.78-2.10; P=0.049), TAS lt 1.25mmol/L (OR: 5.77; 95% CI 0.98-367.0; P lt 0.000), ferritin lt 84.8pg/mL (OR: 2.52; 95% CI 1.37-4.62; P=0.002), and haptoglobin lt 1.51g/L (OR: 1.94; 95% CI 1.05-3.56; P=0.031) was found with the AMD. According to receiver operating characteristic curve analysis, ferritin concentration lt 84.8pg/L, GPx lt 27U/gHb, and TAS lt 1.25mmol/L have sufficient predictive ability for AMD.Conclusion: Significantly reduced capacity of the antioxidant defense system and iron-binding storage proteins (ferritin) found in AMD could have an important role in the development of increase oxidative stress in AMD patients.
Keywords:
Oxidative stress / antioxidant defense parameters / iron / iron-binding proteinsSource:
Current Eye Research, 2018, 43, 5, 659-665Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-MESTD-Basic Research (BR or ON)-175036)
DOI: 10.1080/02713683.2018.1437452
ISSN: 0271-3683
PubMed: 29448841
WoS: 000430092800013
Scopus: 2-s2.0-85042214258
Collections
Institution/Community
PharmacyTY - JOUR AU - Čolak, Emina AU - Zorić, Lepša AU - Radosavljević, Aleksandra AU - Ignjatović, Svetlana PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3157 AB - Purpose: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD. In addition, the aim was to examine the gender differences and calculate the cutoff points of tested parameters that could be associated with AMD.Material and methods: A cross-sectional study included 55 AMD patients aged 71.77.36 years and 65 aged-matched control subjects aged 70.256.46years.Results: Significantly lower ferritin (P=0.025), SOD (P=0.026), GPx (P=0.019), and TAS (P lt 0.004) values were found in patients with AMD compared to the controls (P lt 0.05). Significant association of GPx lt 27U/gHb (odds ratio [OR]: 1.13; 95% confidence interval [CI] 0.78-2.10; P=0.049), TAS lt 1.25mmol/L (OR: 5.77; 95% CI 0.98-367.0; P lt 0.000), ferritin lt 84.8pg/mL (OR: 2.52; 95% CI 1.37-4.62; P=0.002), and haptoglobin lt 1.51g/L (OR: 1.94; 95% CI 1.05-3.56; P=0.031) was found with the AMD. According to receiver operating characteristic curve analysis, ferritin concentration lt 84.8pg/L, GPx lt 27U/gHb, and TAS lt 1.25mmol/L have sufficient predictive ability for AMD.Conclusion: Significantly reduced capacity of the antioxidant defense system and iron-binding storage proteins (ferritin) found in AMD could have an important role in the development of increase oxidative stress in AMD patients. PB - Taylor & Francis Inc, Philadelphia T2 - Current Eye Research T1 - The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration VL - 43 IS - 5 SP - 659 EP - 665 DO - 10.1080/02713683.2018.1437452 ER -
@article{ author = "Čolak, Emina and Zorić, Lepša and Radosavljević, Aleksandra and Ignjatović, Svetlana", year = "2018", abstract = "Purpose: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD. In addition, the aim was to examine the gender differences and calculate the cutoff points of tested parameters that could be associated with AMD.Material and methods: A cross-sectional study included 55 AMD patients aged 71.77.36 years and 65 aged-matched control subjects aged 70.256.46years.Results: Significantly lower ferritin (P=0.025), SOD (P=0.026), GPx (P=0.019), and TAS (P lt 0.004) values were found in patients with AMD compared to the controls (P lt 0.05). Significant association of GPx lt 27U/gHb (odds ratio [OR]: 1.13; 95% confidence interval [CI] 0.78-2.10; P=0.049), TAS lt 1.25mmol/L (OR: 5.77; 95% CI 0.98-367.0; P lt 0.000), ferritin lt 84.8pg/mL (OR: 2.52; 95% CI 1.37-4.62; P=0.002), and haptoglobin lt 1.51g/L (OR: 1.94; 95% CI 1.05-3.56; P=0.031) was found with the AMD. According to receiver operating characteristic curve analysis, ferritin concentration lt 84.8pg/L, GPx lt 27U/gHb, and TAS lt 1.25mmol/L have sufficient predictive ability for AMD.Conclusion: Significantly reduced capacity of the antioxidant defense system and iron-binding storage proteins (ferritin) found in AMD could have an important role in the development of increase oxidative stress in AMD patients.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Current Eye Research", title = "The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration", volume = "43", number = "5", pages = "659-665", doi = "10.1080/02713683.2018.1437452" }
Čolak, E., Zorić, L., Radosavljević, A.,& Ignjatović, S.. (2018). The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration. in Current Eye Research Taylor & Francis Inc, Philadelphia., 43(5), 659-665. https://doi.org/10.1080/02713683.2018.1437452
Čolak E, Zorić L, Radosavljević A, Ignjatović S. The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration. in Current Eye Research. 2018;43(5):659-665. doi:10.1080/02713683.2018.1437452 .
Čolak, Emina, Zorić, Lepša, Radosavljević, Aleksandra, Ignjatović, Svetlana, "The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration" in Current Eye Research, 43, no. 5 (2018):659-665, https://doi.org/10.1080/02713683.2018.1437452 . .