An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems
Samo za registrovane korisnike
2018
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Contemporary trends in the pharmaceutical development emphasize the utility of advanced computer tools to facilitate formulation of new medicines. A special attention has been given to the formulation and characterization of dosage forms for targeted drug delivery that can improve therapeutic outcome. The objective of this study was to apply the combined in vitro-in silico approach to optimize the design of gastroretentive floating system for sustained release of ranitidine hydrochloride. Formulation of the floating systems was based on the effervescent effect of sodium-bicarbonate, whereas prolonged release of ranitidine hydrochloride was provided by the hydrophilic polyethylene oxide polymers which swell and form a gel layer on the surface of the floating tablets. Dosage form floating characteristics and drug dissolution were investigated under biorelevant conditions simulating stomach environment. The obtained dissolution data were used as inputs in ranitidine-specific physiological...ly-based pharmacokinetic model within GastroPlus (TM) software to predict the expected pharmacokinetic profiles following oral administration of the designed formulations. The predictive power of the designed model was tested by comparing the simulation outcomes with literature values on drug plasma concentration-time profiles following intravenous and oral administration of different ranitidine doses. In addition, simulation results demonstrated increased extent of drug absorption with prolonged gastric residence times.
Ključne reči:
Ranitidine / Polyethylene oxide / Dissolution / Absorption / Physiologically-based pharmacokinetic / modelingIzvor:
Journal of Drug Delivery Science and Technology, 2018, 45, 1-10Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1016/j.jddst.2018.02.013
ISSN: 1773-2247
WoS: 000438498100001
Scopus: 2-s2.0-85042713778
Institucija/grupa
PharmacyTY - JOUR AU - Cvijić, Sandra AU - Ibrić, Svetlana AU - Parojčić, Jelena AU - Đuriš, Jelena PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3198 AB - Contemporary trends in the pharmaceutical development emphasize the utility of advanced computer tools to facilitate formulation of new medicines. A special attention has been given to the formulation and characterization of dosage forms for targeted drug delivery that can improve therapeutic outcome. The objective of this study was to apply the combined in vitro-in silico approach to optimize the design of gastroretentive floating system for sustained release of ranitidine hydrochloride. Formulation of the floating systems was based on the effervescent effect of sodium-bicarbonate, whereas prolonged release of ranitidine hydrochloride was provided by the hydrophilic polyethylene oxide polymers which swell and form a gel layer on the surface of the floating tablets. Dosage form floating characteristics and drug dissolution were investigated under biorelevant conditions simulating stomach environment. The obtained dissolution data were used as inputs in ranitidine-specific physiologically-based pharmacokinetic model within GastroPlus (TM) software to predict the expected pharmacokinetic profiles following oral administration of the designed formulations. The predictive power of the designed model was tested by comparing the simulation outcomes with literature values on drug plasma concentration-time profiles following intravenous and oral administration of different ranitidine doses. In addition, simulation results demonstrated increased extent of drug absorption with prolonged gastric residence times. PB - Elsevier Science BV, Amsterdam T2 - Journal of Drug Delivery Science and Technology T1 - An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems VL - 45 SP - 1 EP - 10 DO - 10.1016/j.jddst.2018.02.013 ER -
@article{ author = "Cvijić, Sandra and Ibrić, Svetlana and Parojčić, Jelena and Đuriš, Jelena", year = "2018", abstract = "Contemporary trends in the pharmaceutical development emphasize the utility of advanced computer tools to facilitate formulation of new medicines. A special attention has been given to the formulation and characterization of dosage forms for targeted drug delivery that can improve therapeutic outcome. The objective of this study was to apply the combined in vitro-in silico approach to optimize the design of gastroretentive floating system for sustained release of ranitidine hydrochloride. Formulation of the floating systems was based on the effervescent effect of sodium-bicarbonate, whereas prolonged release of ranitidine hydrochloride was provided by the hydrophilic polyethylene oxide polymers which swell and form a gel layer on the surface of the floating tablets. Dosage form floating characteristics and drug dissolution were investigated under biorelevant conditions simulating stomach environment. The obtained dissolution data were used as inputs in ranitidine-specific physiologically-based pharmacokinetic model within GastroPlus (TM) software to predict the expected pharmacokinetic profiles following oral administration of the designed formulations. The predictive power of the designed model was tested by comparing the simulation outcomes with literature values on drug plasma concentration-time profiles following intravenous and oral administration of different ranitidine doses. In addition, simulation results demonstrated increased extent of drug absorption with prolonged gastric residence times.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Drug Delivery Science and Technology", title = "An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems", volume = "45", pages = "1-10", doi = "10.1016/j.jddst.2018.02.013" }
Cvijić, S., Ibrić, S., Parojčić, J.,& Đuriš, J.. (2018). An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems. in Journal of Drug Delivery Science and Technology Elsevier Science BV, Amsterdam., 45, 1-10. https://doi.org/10.1016/j.jddst.2018.02.013
Cvijić S, Ibrić S, Parojčić J, Đuriš J. An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems. in Journal of Drug Delivery Science and Technology. 2018;45:1-10. doi:10.1016/j.jddst.2018.02.013 .
Cvijić, Sandra, Ibrić, Svetlana, Parojčić, Jelena, Đuriš, Jelena, "An in vitro - in silico approach for the formulation and characterization of ranitidine gastroretentive delivery systems" in Journal of Drug Delivery Science and Technology, 45 (2018):1-10, https://doi.org/10.1016/j.jddst.2018.02.013 . .