Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent
Само за регистроване кориснике
2018
Аутори
Osmokrović, AndreaJančić, Ivan
Vunduk, Jovana
Petrović, Predrag
Milenković, Marina
Obradović, Bojana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provi...de utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption.
Кључне речи:
Alginate / Activated charcoal / Povidone iodine / Antibacterial activity / Wound dressingИзвор:
Carbohydrate Polymers, 2018, 196, 279-288Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Синтеза, развој технологија добијања и примена наноструктурних мултифункционалних материјала дефинисаних својстава (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45019)
DOI: 10.1016/j.carbpol.2018.05.045
ISSN: 0144-8617
PubMed: 29891298
WoS: 000436571600032
Scopus: 2-s2.0-85047260873
Институција/група
PharmacyTY - JOUR AU - Osmokrović, Andrea AU - Jančić, Ivan AU - Vunduk, Jovana AU - Petrović, Predrag AU - Milenković, Marina AU - Obradović, Bojana PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3240 AB - New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption. PB - Elsevier Sci Ltd, Oxford T2 - Carbohydrate Polymers T1 - Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent VL - 196 SP - 279 EP - 288 DO - 10.1016/j.carbpol.2018.05.045 ER -
@article{ author = "Osmokrović, Andrea and Jančić, Ivan and Vunduk, Jovana and Petrović, Predrag and Milenković, Marina and Obradović, Bojana", year = "2018", abstract = "New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Carbohydrate Polymers", title = "Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent", volume = "196", pages = "279-288", doi = "10.1016/j.carbpol.2018.05.045" }
Osmokrović, A., Jančić, I., Vunduk, J., Petrović, P., Milenković, M.,& Obradović, B.. (2018). Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. in Carbohydrate Polymers Elsevier Sci Ltd, Oxford., 196, 279-288. https://doi.org/10.1016/j.carbpol.2018.05.045
Osmokrović A, Jančić I, Vunduk J, Petrović P, Milenković M, Obradović B. Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent. in Carbohydrate Polymers. 2018;196:279-288. doi:10.1016/j.carbpol.2018.05.045 .
Osmokrović, Andrea, Jančić, Ivan, Vunduk, Jovana, Petrović, Predrag, Milenković, Marina, Obradović, Bojana, "Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent" in Carbohydrate Polymers, 196 (2018):279-288, https://doi.org/10.1016/j.carbpol.2018.05.045 . .
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