Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population
Апстракт
Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt... 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.
Кључне речи:
fatty liver / hyperuricemia / inflammation / obesity / transaminasesИзвор:
Journal of Medical Biochemistry, 2019Издавач:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.2478/jomb-2019-0001
ISSN: 1452-8258
WoS: 000478797600002
Scopus: 2-s2.0-85063750687
Институција/група
PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kavarić, Nebojša AU - Ninić, Ana PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3288 AB - Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population DO - 10.2478/jomb-2019-0001 ER -
@article{ author = "Klisić, Aleksandra and Kavarić, Nebojša and Ninić, Ana", year = "2019", abstract = "Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population", doi = "10.2478/jomb-2019-0001" }
Klisić, A., Kavarić, N.,& Ninić, A.. (2019). Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita.. https://doi.org/10.2478/jomb-2019-0001
Klisić A, Kavarić N, Ninić A. Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population. in Journal of Medical Biochemistry. 2019;. doi:10.2478/jomb-2019-0001 .
Klisić, Aleksandra, Kavarić, Nebojša, Ninić, Ana, "Predictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin population" in Journal of Medical Biochemistry (2019), https://doi.org/10.2478/jomb-2019-0001 . .