Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography
Samo za registrovane korisnike
2019
Autori
Obradović, DarijaJovanović, Dušan
Pesić, Suncica
Tomić, Jovana
Oljačić, Slavica
Nikolić, Katarina
Agbaba, Danica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The retention behavior of ivabradine, its 11 related compounds, diltiazem and verapamil has been examined by thin-layer chromatography using non-polar stationary phase (RP-18) and the following mobile phases: methanol-6.25% aqueous ammonia, tetrahydrofuran - 6.25% aqueous ammonia, and also polar stationary phase (silica gel) with tetrahydrofuran - 6.25% methanolic ammonia as mobile phase. In the examined chromatographic systems, linear relationships were established between the retention coefficients, R-M(0) and m, and molecular properties of the investigated antiarrhythmic drugs. The Quantitative Structure Retention Relationship (QSRR) modeling was performed with use of the stepwise multiple linear regression, in order to select the most important molecular properties which influence the retention behavior. The developed models revealed that apart from lipophilicity also the molecular volume (V), and the hydrogen bond basicity (B) of the tested compounds are the most important for the... retention behavior in the examined chromatographic systems.
Ključne reči:
Ivabradine / related compounds / retention mechanism / TLCIzvor:
Journal of Liquid Chromatography & Related Technologies, 2019, 1-7Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
DOI: 10.1080/10826076.2019.1585613
ISSN: 1082-6076
WoS: 000465710000001
Scopus: 2-s2.0-85063991930
Institucija/grupa
PharmacyTY - JOUR AU - Obradović, Darija AU - Jovanović, Dušan AU - Pesić, Suncica AU - Tomić, Jovana AU - Oljačić, Slavica AU - Nikolić, Katarina AU - Agbaba, Danica PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3368 AB - The retention behavior of ivabradine, its 11 related compounds, diltiazem and verapamil has been examined by thin-layer chromatography using non-polar stationary phase (RP-18) and the following mobile phases: methanol-6.25% aqueous ammonia, tetrahydrofuran - 6.25% aqueous ammonia, and also polar stationary phase (silica gel) with tetrahydrofuran - 6.25% methanolic ammonia as mobile phase. In the examined chromatographic systems, linear relationships were established between the retention coefficients, R-M(0) and m, and molecular properties of the investigated antiarrhythmic drugs. The Quantitative Structure Retention Relationship (QSRR) modeling was performed with use of the stepwise multiple linear regression, in order to select the most important molecular properties which influence the retention behavior. The developed models revealed that apart from lipophilicity also the molecular volume (V), and the hydrogen bond basicity (B) of the tested compounds are the most important for the retention behavior in the examined chromatographic systems. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography SP - 1 EP - 7 DO - 10.1080/10826076.2019.1585613 ER -
@article{ author = "Obradović, Darija and Jovanović, Dušan and Pesić, Suncica and Tomić, Jovana and Oljačić, Slavica and Nikolić, Katarina and Agbaba, Danica", year = "2019", abstract = "The retention behavior of ivabradine, its 11 related compounds, diltiazem and verapamil has been examined by thin-layer chromatography using non-polar stationary phase (RP-18) and the following mobile phases: methanol-6.25% aqueous ammonia, tetrahydrofuran - 6.25% aqueous ammonia, and also polar stationary phase (silica gel) with tetrahydrofuran - 6.25% methanolic ammonia as mobile phase. In the examined chromatographic systems, linear relationships were established between the retention coefficients, R-M(0) and m, and molecular properties of the investigated antiarrhythmic drugs. The Quantitative Structure Retention Relationship (QSRR) modeling was performed with use of the stepwise multiple linear regression, in order to select the most important molecular properties which influence the retention behavior. The developed models revealed that apart from lipophilicity also the molecular volume (V), and the hydrogen bond basicity (B) of the tested compounds are the most important for the retention behavior in the examined chromatographic systems.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography", pages = "1-7", doi = "10.1080/10826076.2019.1585613" }
Obradović, D., Jovanović, D., Pesić, S., Tomić, J., Oljačić, S., Nikolić, K.,& Agbaba, D.. (2019). Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 1-7. https://doi.org/10.1080/10826076.2019.1585613
Obradović D, Jovanović D, Pesić S, Tomić J, Oljačić S, Nikolić K, Agbaba D. Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography. in Journal of Liquid Chromatography & Related Technologies. 2019;:1-7. doi:10.1080/10826076.2019.1585613 .
Obradović, Darija, Jovanović, Dušan, Pesić, Suncica, Tomić, Jovana, Oljačić, Slavica, Nikolić, Katarina, Agbaba, Danica, "Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography" in Journal of Liquid Chromatography & Related Technologies (2019):1-7, https://doi.org/10.1080/10826076.2019.1585613 . .