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TLC determination of glimepiride and its main impurities in pharmaceuticals
dc.creator | Topić, Valentina | |
dc.creator | Filipić, Slavica | |
dc.creator | Popović, Gordana | |
dc.creator | Nikolić, Katarina | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-14T21:32:28Z | |
dc.date.available | 2014-04-09 | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3435 | |
dc.description.abstract | A quantitative TLC method was developed for the simultaneous separation and quantification of glimepiride and its main degradation impurities, glimepiride-sulfonamide, and glimepiride-carbamate. Chromatographic analysis was performed using the commercial aluminum-backed TLC plates precoated with silica gel 60F(254) as stationary phase and toluene-ethyl acetate-methanol 8:5:1 (v/v) as the mobile phase. Detection was performed at 230nm. Regression coefficients (r>0.997), recovery (94.9 to 105.1%), determination limit of impurities (7ng spot(-1) equivalent to the 0.1% impurity level), and robustness were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of glimepiride in its dosage forms. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Liquid Chromatography & Related Technologies | |
dc.subject | glimepiride | en |
dc.subject | hypoglycemic drug | en |
dc.subject | impurities | en |
dc.subject | pharmaceutical dosage forms | en |
dc.subject | quantification | en |
dc.subject | TLC | en |
dc.title | TLC determination of glimepiride and its main impurities in pharmaceuticals | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Топић, Валентина; Aгбаба, Даница; Николић, Катарина; Поповић, Гордана; Филипић, Славица; | |
dc.citation.volume | 36 | |
dc.citation.issue | 17 | |
dc.citation.spage | 2422 | |
dc.citation.epage | 2430 | |
dc.citation.other | 36(17): 2422-2430 | |
dc.citation.rank | M23 | |
dc.description.other | This is peer-reviewed version of the following article: Topić, V.; Filipić, S.; Popović, G.; Nikolić, K.; Agbaba, D. TLC Determination of Glimepiride and Its Main Impurities in Pharmaceuticals. J. Liq. Chromatogr. Relat. Technol. 2013, 36 (17), 2422–2430. [https://doi.org/10.1080/10826076.2013.790767] | |
dc.identifier.wos | 000321812900008 | |
dc.identifier.doi | 10.1080/10826076.2013.790767 | |
dc.identifier.scopus | 2-s2.0-84880376950 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/7140/TLC_determination_of_acc_2013.pdf | |
dc.type.version | acceptedVersion | |
dc.type.version | publishedVersion |