A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead
Autori
Bjørklund, GeirCrisponi, Guido
Nurchi, Valeria Marina
Cappai, Rosita
Buha-Đorđević, Aleksandra
Aaseth, Jan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical pr...actice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics.
Ključne reči:
BAL / DMPS / DMSA / Metal chelator / Metal ionIzvor:
Molecules, 2019, 24, 3247, 1-32Izdavač:
- MDPI
Finansiranje / projekti:
- VMN thanks Regione Autonoma della Sardegna - RASSR79857 “Metallo-farmaci innovativi: biotrasformazione e target biologici. Un approccio integrato”.
- Innovation Sciences and Technologies (PON RI 2014-2020) at the University of Cagliari.
- Unapređenje i razvoj higijenskih i tehnoloških postupaka u proizvodnji namirnica životinjskog porekla u cilju dobijanja kvalitetnih i bezbednih proizvoda konkurentnih na svetskom tržištu (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
DOI: 10.3390/molecules24183247
ISSN: 1420-3049
PubMed: 31489907
WoS: 000488830500039
Scopus: 2-s2.0-85071777914
Institucija/grupa
PharmacyTY - JOUR AU - Bjørklund, Geir AU - Crisponi, Guido AU - Nurchi, Valeria Marina AU - Cappai, Rosita AU - Buha-Đorđević, Aleksandra AU - Aaseth, Jan PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3460 AB - The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics. PB - MDPI T2 - Molecules T1 - A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead VL - 24 IS - 3247 SP - 1 EP - 32 DO - 10.3390/molecules24183247 ER -
@article{ author = "Bjørklund, Geir and Crisponi, Guido and Nurchi, Valeria Marina and Cappai, Rosita and Buha-Đorđević, Aleksandra and Aaseth, Jan", year = "2019", abstract = "The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics.", publisher = "MDPI", journal = "Molecules", title = "A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead", volume = "24", number = "3247", pages = "1-32", doi = "10.3390/molecules24183247" }
Bjørklund, G., Crisponi, G., Nurchi, V. M., Cappai, R., Buha-Đorđević, A.,& Aaseth, J.. (2019). A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead. in Molecules MDPI., 24(3247), 1-32. https://doi.org/10.3390/molecules24183247
Bjørklund G, Crisponi G, Nurchi VM, Cappai R, Buha-Đorđević A, Aaseth J. A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead. in Molecules. 2019;24(3247):1-32. doi:10.3390/molecules24183247 .
Bjørklund, Geir, Crisponi, Guido, Nurchi, Valeria Marina, Cappai, Rosita, Buha-Đorđević, Aleksandra, Aaseth, Jan, "A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead" in Molecules, 24, no. 3247 (2019):1-32, https://doi.org/10.3390/molecules24183247 . .