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Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease
dc.creator | Miletić Vukajlović, Jadranka | |
dc.creator | Drakulić, Dunja | |
dc.creator | Pejić, Snežana | |
dc.creator | Ilić, Tihomir V. | |
dc.creator | Stefanović, Aleksandra | |
dc.creator | Petković, Marijana | |
dc.creator | Schiller, Jürgen | |
dc.date.accessioned | 2020-02-20T12:24:41Z | |
dc.date.available | 2020-02-20T12:24:41Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0951-4198 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3522 | |
dc.description.abstract | Rationale: Changes in lipid composition might be associated with the onset and progression of various neurodegenerative diseases. Herein, we investigated the changes in the plasma phosphatidylcholine (PC)/lysophosphatidylcholine (LPC) ratios in patients with Parkinson's disease (PD) in comparison with healthy subjects and their correlation with clinico-pathological features. Methods: The study included 10 controls and 25 patients with PD. All patients were assigned to groups based on clinico-pathological characteristics (gender, age at examination, duration of disease and Hoehn and Yahr (H&Y) stage). The analysis of the PC/LPC intensity ratios in plasma lipid extracts was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: PD patients exhibited an increased PC/LPC intensity ratio in comparison with the control group of healthy subjects. Furthermore, the investigated ratio was shown to be correlated with clinico-pathological parameters, in particular with H&Y stage and disease duration. The PC/LPC intensity ratio in plasma samples of PD patients was found to be elevated in all examined H&Y stages and throughout the disease duration. Conclusions: To our knowledge, this is the first study examining the PC/LPC ratios in plasma of patients with PD and illustrating their correlation with clinico-pathological features. Although the presented results may be considered as preliminary due to the limited number of participants, the observed alterations of PC/LPC ratios in plasma might be a first step in the characterization of plasma lipid changes in PD patients and an indicator of lipid reconfiguration. | en |
dc.publisher | John Wiley and Sons Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS// | |
dc.rights | restrictedAccess | |
dc.source | Rapid Communications in Mass Spectrometry | |
dc.subject | MALDI-TOF MS | |
dc.subject | PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE ACTIVITY | |
dc.subject | PHOSPHOLIPASE A(2) ACTIVITY | |
dc.subject | LIPID-PEROXIDATION | |
dc.subject | MASS-SPECTROMETRY | |
dc.subject | O-ACYLTRANSFERASE | |
dc.subject | SUBSTANTIA-NIGRA | |
dc.subject | OXIDATIVE STRESS | |
dc.subject | FATTY-ACID | |
dc.subject | LYSOPHOSPHATIDYLCHOLINE | |
dc.title | Increased plasma phosphatidylcholine/lysophosphatidylcholine ratios in patients with Parkinson's disease | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Петковић, Маријана; Милетић Вукајловић, Јадранка; Сцхиллер, Јüрген; Дракулић, Дуња; Пејић, Снежана; Илић, Тихомир В.; Стефановић, Aлександра; | |
dc.citation.volume | 34 | |
dc.citation.issue | 4 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000508347200007 | |
dc.identifier.doi | 10.1002/rcm.8595 | |
dc.identifier.scopus | 2-s2.0-85078298349 | |
dc.type.version | publishedVersion |