Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate
Samo za registrovane korisnike
2019
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer a...nd excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release.
Ključne reči:
Digital Light Processing (DLP) / Photopolymerization / Sustained release / Three-dimensional (3D) printingIzvor:
International Journal of Pharmaceutics, 2019, 572Izdavač:
- Elsevier
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1016/j.ijpharm.2019.118790
ISSN: 0378-5173
WoS: 000500308000048
Scopus: 2-s2.0-85075486961
Institucija/grupa
PharmacyTY - JOUR AU - Krkobabić, Mirjana AU - Medarević, Đorđe AU - Cvijić, Sandra AU - Grujić, Branka AU - Ibrić, Svetlana PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3540 AB - Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer and excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release. PB - Elsevier T2 - International Journal of Pharmaceutics T1 - Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate VL - 572 DO - 10.1016/j.ijpharm.2019.118790 ER -
@article{ author = "Krkobabić, Mirjana and Medarević, Đorđe and Cvijić, Sandra and Grujić, Branka and Ibrić, Svetlana", year = "2019", abstract = "Three-dimensional (3D) printing enables the production of different objects adjusted for the specific application, which has particular importance of providing personalized therapy, whereby the challenge is to apply pharmaceutical materials into 3D printing technology. In this study, effect of poly(ethylene glycol) 400 (PEG 400), sodium chloride (NaCl), and mannitol, as hydrophilic excipients, was investigated in order to overcome very slow and incomplete drug release from tablets (printlets) fabricated by photopolymerization using digital light processing (DLP) technology. Paracetamol (acetaminophen) was used as a model drug, while polyethylene glycol diacrylate (PEGDA) was used as a photopolymer and diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide as a photoinitiator in photoreactive mixtures. Most of printlet formulations exhibit sustained release over 8 h, wherein drug release kinetics is the best described with Korsmeyer-Peppas kinetics. Variation in the content of photopolymer and excipients had an influence on the dissolution rate, mechanical characteristics, and internal structure of the investigated samples. The addition of hydrophilic polymers increased drug release rate, while PEGDA had the greatest influence on the tensile strength of printlets. The results indicate the possibility of implementation of traditional excipients into different formulations for photopolymerization based 3D printing for the production of small batches of tablets with tailored drug release.", publisher = "Elsevier", journal = "International Journal of Pharmaceutics", title = "Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate", volume = "572", doi = "10.1016/j.ijpharm.2019.118790" }
Krkobabić, M., Medarević, Đ., Cvijić, S., Grujić, B.,& Ibrić, S.. (2019). Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate. in International Journal of Pharmaceutics Elsevier., 572. https://doi.org/10.1016/j.ijpharm.2019.118790
Krkobabić M, Medarević Đ, Cvijić S, Grujić B, Ibrić S. Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate. in International Journal of Pharmaceutics. 2019;572. doi:10.1016/j.ijpharm.2019.118790 .
Krkobabić, Mirjana, Medarević, Đorđe, Cvijić, Sandra, Grujić, Branka, Ibrić, Svetlana, "Hydrophilic excipients in digital light processing (DLP) printing of sustained release tablets: Impact on internal structure and drug dissolution rate" in International Journal of Pharmaceutics, 572 (2019), https://doi.org/10.1016/j.ijpharm.2019.118790 . .