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Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception
dc.creator | Pecikoza, Uroš | |
dc.creator | Tomić, Maja | |
dc.creator | Micov, Ana | |
dc.creator | Vuković, Milja | |
dc.creator | Stepanović-Petrović, Radica | |
dc.date.accessioned | 2020-03-04T08:41:23Z | |
dc.date.available | 2020-03-04T08:41:23Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0033-3158 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3547 | |
dc.description.abstract | Rationale: Acute pain states in the trigeminal region (headaches, dental pain) fall into the most prevalent painful conditions. Standard analgesics (paracetamol/NSAIDs) represent the cornerstone of their treatment, whereas triptans are primarily used in migraine attacks. Due to limited efficacy and/or side effects of current treatments, identifying favorable combinations of available drugs is justified. Objectives: Eslicarbazepine acetate (ESL) is a novel antiepileptic drug whose effectiveness against trigeminal pain was recently demonstrated. Here, we examined the interactions between ESL and several standard/alternative analgesics (paracetamol, propyphenazone, naproxen, zolmitriptan, and metoclopramide) in a model of trigeminal pain. Methods: The antinociceptive effects of orally administered ESL, standard/alternative analgesics, and two-drug ESL-analgesic combinations were examined in the orofacial formalin test in mice. The type of interaction between drugs was determined by isobolographic analysis. Results: ESL, analgesics, and two-drug ESL-analgesic combinations significantly and dose-dependently reduced nociceptive behaviour in the second, inflammatory phase of the test. Isobolographic analysis revealed that ESL interacted additively with paracetamol/propyphenazone/zolmitriptan and synergistically with naproxen/metoclopramide (with about a 4-fold and 3-fold reduction of doses in the ESL-naproxen and ESL-metoclopramide combination, respectively). Conclusions: ESL interacted in a beneficial manner with several analgesics that are used for trigeminal pain treatment, producing synergistic interactions with naproxen/metoclopramide and additive interactions with paracetamol/propyphenazone/zolmitriptan. Our results suggest that combining ESL with analgesics could theoretically enable the use of lower doses of individual drugs for achieving pain relief. | en |
dc.publisher | Springer Nature | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175045/RS// | |
dc.rights | restrictedAccess | |
dc.source | Psychopharmacology | |
dc.subject | Eslicarbazepine acetate | |
dc.subject | Isobolographic analysis | |
dc.subject | Metoclopramide | |
dc.subject | Non-opioid analgesics | |
dc.subject | Orofacial nociception | |
dc.subject | Triptans | |
dc.title | Eslicarbazepine acetate interacts in a beneficial manner with standard and alternative analgesics to reduce trigeminal nociception | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вуковић, Миља; Пецикоза, Урош; Томић, Маја; Мицов, Aна; Степановић-Петровић, Радица; | |
dc.citation.volume | 237 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1435 | |
dc.citation.epage | 1446 | |
dc.citation.rank | M21 | |
dc.description.other | Peer-reviewd manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3546] | |
dc.identifier.wos | 000515840900001 | |
dc.identifier.doi | 10.1007/s00213-020-05470-7 | |
dc.identifier.scopus | 2-s2.0-85079176511 | |
dc.type.version | publishedVersion |