Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery
Само за регистроване кориснике
2021
Аутори
Ignjatović, JelisavetaĐuriš, Jelena
Cvijić, Sandra
Dobričić, Vladimir
Montepietra, Agnese
Lombardi, Chiara
Ibrić, Svetlana
Rossi, Alessandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfat...e release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs.
Кључне речи:
Dry powders for inhalation / Melt-emulsification / Quality target product profile / Solid lipid microparticles / Spray-dryingИзвор:
European Journal of Pharmaceutical Sciences, 2021, 156Издавач:
- Elsevier B.V.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.ejps.2020.105588
ISSN: 0928-0987
WoS: 000597380300006
Scopus: 2-s2.0-85092729637
Институција/група
PharmacyTY - JOUR AU - Ignjatović, Jelisaveta AU - Đuriš, Jelena AU - Cvijić, Sandra AU - Dobričić, Vladimir AU - Montepietra, Agnese AU - Lombardi, Chiara AU - Ibrić, Svetlana AU - Rossi, Alessandra PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3709 AB - The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfate release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs. PB - Elsevier B.V. T2 - European Journal of Pharmaceutical Sciences T1 - Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery VL - 156 DO - 10.1016/j.ejps.2020.105588 ER -
@article{ author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Cvijić, Sandra and Dobričić, Vladimir and Montepietra, Agnese and Lombardi, Chiara and Ibrić, Svetlana and Rossi, Alessandra", year = "2021", abstract = "The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic performance and salbutamol sulfate release rate. Quality target product profile was identified and risk management and principal component analysis were used to guide formulation development. Obtained dry powders for inhalation (DPIs) were evaluated in terms of SLMs size distribution, morphology, true density, drug content, solid state characterization studies, in vitro aerosol performance and in vitro drug release. SLMs micrographs indicated spherical, porous particles. Selected powders showed satisfactory aerosol performance with a mean mass aerodynamic diameter of around 3 μm and acceptable fine particle fraction (FPF). Addition of trehalose positively affected SLMs aerodynamic properties. The results of in vitro dissolution testing indicated that salbutamol sulfate release from the tested SLMs formulations was modified, in comparison to the raw drug release. In conclusion, SLMs in a form of DPIs were successfully developed and numerous factors that affects SLMs properties were identified in this study. Further research is required for full understanding of each factor's influence on SLMs properties and optimization of DPIs with maximized FPFs.", publisher = "Elsevier B.V.", journal = "European Journal of Pharmaceutical Sciences", title = "Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery", volume = "156", doi = "10.1016/j.ejps.2020.105588" }
Ignjatović, J., Đuriš, J., Cvijić, S., Dobričić, V., Montepietra, A., Lombardi, C., Ibrić, S.,& Rossi, A.. (2021). Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery. in European Journal of Pharmaceutical Sciences Elsevier B.V.., 156. https://doi.org/10.1016/j.ejps.2020.105588
Ignjatović J, Đuriš J, Cvijić S, Dobričić V, Montepietra A, Lombardi C, Ibrić S, Rossi A. Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery. in European Journal of Pharmaceutical Sciences. 2021;156. doi:10.1016/j.ejps.2020.105588 .
Ignjatović, Jelisaveta, Đuriš, Jelena, Cvijić, Sandra, Dobričić, Vladimir, Montepietra, Agnese, Lombardi, Chiara, Ibrić, Svetlana, Rossi, Alessandra, "Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery" in European Journal of Pharmaceutical Sciences, 156 (2021), https://doi.org/10.1016/j.ejps.2020.105588 . .