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Preparation of floating polymer-valsartan delivery systems using supercritical CO2
dc.creator | Milovanović, Stoja | |
dc.creator | Đuriš, Jelena | |
dc.creator | Dapčević, Aleksandra | |
dc.creator | Lučić-Škorić, Marija | |
dc.creator | Medarević, Đorđe | |
dc.creator | Pavlović, Stefan | |
dc.creator | Ibrić, Svetlana | |
dc.date.accessioned | 2021-02-17T13:59:53Z | |
dc.date.available | 2021-02-17T13:59:53Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1022-9760 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3782 | |
dc.description.abstract | This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process. | |
dc.publisher | Springer Science and Business Media B.V. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Polymer Research | |
dc.subject | Eudragit® E100 | |
dc.subject | HPMCAS | |
dc.subject | Soluplus® | |
dc.subject | Supercritical CO2 | |
dc.subject | Valsartan | |
dc.title | Preparation of floating polymer-valsartan delivery systems using supercritical CO2 | |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Миловановић, Стоја; Ђуриш, Јелена; Медаревић, Ђорђе; Ибрић, Светлана; Дапчевић, Aлександра; Лучић-Шкорић, Марија; Павловић, Стефан; | |
dc.citation.volume | 28 | |
dc.citation.issue | 3 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000616723100002 | |
dc.identifier.doi | 10.1007/s10965-021-02440-1 | |
dc.identifier.scopus | 2-s2.0-85100464987 | |
dc.type.version | publishedVersion |