Revealing the role of high-density lipoprotein in colorectal cancer
Authors
Zeljković, AleksandraVekić, Jelena
Mihajlović, Marija
Gojković, Tamara
Vladimirov, Sandra
Zeljković, Dejan
Spasojević-Kalimanovska, Vesna
Trifunović, Bratislav
Article (Published version)
Metadata
Show full item recordAbstract
Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studieshave also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases inpatients with CRC, but more recently, the focus of investigations has shifted toward the explorationof qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of availableevidences regarding the putative role of HDL in CRC will be presented. We will analyze existingfindings regarding alterations of HDL-C levels but also HDL particle structure and distribution inCRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover,we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL indisturbances of cholesterol traffi...cking in CRC. Finally, possible therapeutic implications related toHDL will be presented. Given the available evidence, future studies are needed to resolve all raisedissues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker,and eventual therapeutic approaches based on HDL.
Keywords:
Cholesterol trafficking / Colorectal cancer / Genetic background / HDL functional properties / HDL particle distribution / High-density lipoprotein / Therapeutic implicationsSource:
International Journal of Molecular Sciences, 2021, 22, 7Publisher:
- MDPI AG
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/ijms22073352
ISSN: 1422-0067
WoS: 000638616800001
Scopus: 2-s2.0-85103044175
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Institution/Community
PharmacyTY - JOUR AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Mihajlović, Marija AU - Gojković, Tamara AU - Vladimirov, Sandra AU - Zeljković, Dejan AU - Spasojević-Kalimanovska, Vesna AU - Trifunović, Bratislav PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3813 AB - Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studieshave also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases inpatients with CRC, but more recently, the focus of investigations has shifted toward the explorationof qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of availableevidences regarding the putative role of HDL in CRC will be presented. We will analyze existingfindings regarding alterations of HDL-C levels but also HDL particle structure and distribution inCRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover,we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL indisturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related toHDL will be presented. Given the available evidence, future studies are needed to resolve all raisedissues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker,and eventual therapeutic approaches based on HDL. PB - MDPI AG T2 - International Journal of Molecular Sciences T1 - Revealing the role of high-density lipoprotein in colorectal cancer VL - 22 IS - 7 DO - 10.3390/ijms22073352 ER -
@article{ author = "Zeljković, Aleksandra and Vekić, Jelena and Mihajlović, Marija and Gojković, Tamara and Vladimirov, Sandra and Zeljković, Dejan and Spasojević-Kalimanovska, Vesna and Trifunović, Bratislav", year = "2021", abstract = "Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studieshave also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases inpatients with CRC, but more recently, the focus of investigations has shifted toward the explorationof qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of availableevidences regarding the putative role of HDL in CRC will be presented. We will analyze existingfindings regarding alterations of HDL-C levels but also HDL particle structure and distribution inCRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover,we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL indisturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related toHDL will be presented. Given the available evidence, future studies are needed to resolve all raisedissues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker,and eventual therapeutic approaches based on HDL.", publisher = "MDPI AG", journal = "International Journal of Molecular Sciences", title = "Revealing the role of high-density lipoprotein in colorectal cancer", volume = "22", number = "7", doi = "10.3390/ijms22073352" }
Zeljković, A., Vekić, J., Mihajlović, M., Gojković, T., Vladimirov, S., Zeljković, D., Spasojević-Kalimanovska, V.,& Trifunović, B.. (2021). Revealing the role of high-density lipoprotein in colorectal cancer. in International Journal of Molecular Sciences MDPI AG., 22(7). https://doi.org/10.3390/ijms22073352
Zeljković A, Vekić J, Mihajlović M, Gojković T, Vladimirov S, Zeljković D, Spasojević-Kalimanovska V, Trifunović B. Revealing the role of high-density lipoprotein in colorectal cancer. in International Journal of Molecular Sciences. 2021;22(7). doi:10.3390/ijms22073352 .
Zeljković, Aleksandra, Vekić, Jelena, Mihajlović, Marija, Gojković, Tamara, Vladimirov, Sandra, Zeljković, Dejan, Spasojević-Kalimanovska, Vesna, Trifunović, Bratislav, "Revealing the role of high-density lipoprotein in colorectal cancer" in International Journal of Molecular Sciences, 22, no. 7 (2021), https://doi.org/10.3390/ijms22073352 . .