Cadmium tissue level in women diagnosed with breast cancer – A case control study
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2021
Authors
Anđelković, MilenaBuha-Đorđević, Aleksandra
Antonijević-Miljaković, Evica
Javorac, Dragana
Čolaković, Nataša
Oprić, Svetlana
Petričević, Simona
Granić, Miroslav
Kotur-Stevuljević, Jelena
Antonijević, Biljana
Bulat, Zorica
Article (Published version)
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Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than ...Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.
Keywords:
Cadmium / Breast cancer / Case control study / Hormone status / Redox statusSource:
Environmental Research, 2021, 199Publisher:
- Elsevier
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.1016/j.envres.2021.111300
ISSN: 0013-9351
WoS: 000663723900001
Scopus: 2-s2.0-85107720140
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PharmacyTY - JOUR AU - Anđelković, Milena AU - Buha-Đorđević, Aleksandra AU - Antonijević-Miljaković, Evica AU - Javorac, Dragana AU - Čolaković, Nataša AU - Oprić, Svetlana AU - Petričević, Simona AU - Granić, Miroslav AU - Kotur-Stevuljević, Jelena AU - Antonijević, Biljana AU - Bulat, Zorica PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3915 AB - Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development. PB - Elsevier T2 - Environmental Research T1 - Cadmium tissue level in women diagnosed with breast cancer – A case control study VL - 199 DO - 10.1016/j.envres.2021.111300 ER -
@article{ author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Javorac, Dragana and Čolaković, Nataša and Oprić, Svetlana and Petričević, Simona and Granić, Miroslav and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Bulat, Zorica", year = "2021", abstract = "Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.", publisher = "Elsevier", journal = "Environmental Research", title = "Cadmium tissue level in women diagnosed with breast cancer – A case control study", volume = "199", doi = "10.1016/j.envres.2021.111300" }
Anđelković, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Javorac, D., Čolaković, N., Oprić, S., Petričević, S., Granić, M., Kotur-Stevuljević, J., Antonijević, B.,& Bulat, Z.. (2021). Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research Elsevier., 199. https://doi.org/10.1016/j.envres.2021.111300
Anđelković M, Buha-Đorđević A, Antonijević-Miljaković E, Javorac D, Čolaković N, Oprić S, Petričević S, Granić M, Kotur-Stevuljević J, Antonijević B, Bulat Z. Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research. 2021;199. doi:10.1016/j.envres.2021.111300 .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Javorac, Dragana, Čolaković, Nataša, Oprić, Svetlana, Petričević, Simona, Granić, Miroslav, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Bulat, Zorica, "Cadmium tissue level in women diagnosed with breast cancer – A case control study" in Environmental Research, 199 (2021), https://doi.org/10.1016/j.envres.2021.111300 . .