Investigation into liquisolid system processability based on the SeDeM Expert System approach
Samo za registrovane korisnike
2021
Autori
Vasiljević, IvanaTurković, Erna
Nenadović, Snežana
Mirković, Miljana
Zimmer, Andreas
Parojčić, Jelena
Aleksić, Ivana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically tra...nsformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
Ključne reči:
SeDeM Expert System / Ibuprofen / liquisolid based systems (pellets/admixtures) / single pellet crushing test / water granulated liquisolid systemsIzvor:
International Journal of Pharmaceutics, 2021, 605Izdavač:
- Elsevier B.V.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-200161)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-200017)
DOI: 10.1016/j.ijpharm.2021.120847
ISSN: 0378-5173
WoS: 000692530200002
Scopus: 2-s2.0-85109167364
Institucija/grupa
PharmacyTY - JOUR AU - Vasiljević, Ivana AU - Turković, Erna AU - Nenadović, Snežana AU - Mirković, Miljana AU - Zimmer, Andreas AU - Parojčić, Jelena AU - Aleksić, Ivana PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3921 AB - Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development. PB - Elsevier B.V. T2 - International Journal of Pharmaceutics T1 - Investigation into liquisolid system processability based on the SeDeM Expert System approach VL - 605 DO - 10.1016/j.ijpharm.2021.120847 ER -
@article{ author = "Vasiljević, Ivana and Turković, Erna and Nenadović, Snežana and Mirković, Miljana and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana", year = "2021", abstract = "Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.", publisher = "Elsevier B.V.", journal = "International Journal of Pharmaceutics", title = "Investigation into liquisolid system processability based on the SeDeM Expert System approach", volume = "605", doi = "10.1016/j.ijpharm.2021.120847" }
Vasiljević, I., Turković, E., Nenadović, S., Mirković, M., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics Elsevier B.V.., 605. https://doi.org/10.1016/j.ijpharm.2021.120847
Vasiljević I, Turković E, Nenadović S, Mirković M, Zimmer A, Parojčić J, Aleksić I. Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2021;605. doi:10.1016/j.ijpharm.2021.120847 .
Vasiljević, Ivana, Turković, Erna, Nenadović, Snežana, Mirković, Miljana, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Investigation into liquisolid system processability based on the SeDeM Expert System approach" in International Journal of Pharmaceutics, 605 (2021), https://doi.org/10.1016/j.ijpharm.2021.120847 . .
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