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Neuropharmacokinetics: the secret life of - old and novel - psychopharmacological drugs
(International Association of Physical Chemists, 2023)
Neuro pharmacokinetics: the secret life of - old and novel - psychopharmacological drugs
Miroslav Savić
Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia
In the 21st century, the pace of ...
Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site / Doking studije nekih jedinjenja sa pirazolom u aktivnom mestu ciklooksigenaze-2
(Savez farmaceutskih udruženja Srbije (SFUS), 2023)
Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and
diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors
target cyclooxygenase-2, which is ...
High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances
(Elsevier B.V., 2023)
Preclinical development of deuterated pyrazoloquinolinone ligands, promising drug candidates for various neuropsychiatric disorders, was hindered by unusually low solubility in water and oils. DK-I-60-3 (7-methoxy-d3- ...
A proposal of innovative injectability assessment method for intravenous formulations - case study on PEGylated nanoemulsions
(9th BBBB International conference on pharmaceutical sciences; 15th - 17th September, Ljubljana, Slovenia, 2022)
1. INTRODUCTION
Syringeability and injectability are recognised as fundamental performance parameters / critical quality attributes of any parenteral dosage form. Syringeability refers to the ability of an injectable ...
Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
(MDPI, 2023)
The aim of the study was a synthesis and investigation of the dose-dependent anti-inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines and esters of aromatic amino acids. The results ...
The impact of the aqueous phase on the physicochemical characteristics of nanoemulsions loaded with patent protected compound GL-II-73
(International Society of Drug Delivery Sciences and Technology (APGI)International Association for Pharmaceutical Technology (APV)Italian Society of Technology and Legislation (S.T.E.L.F), 2024)
INTRODUCTION Temporal lobe epilepsy is characterized by seizures, but can also be associated with mental health problems for which there are no clear treatment regimens. A proprietary compound, GL-II-73 - (4R)-8-ethynyl- ...
Selected thiourea derivatives of naproxen as potential anti-inflammatory agents: in vivo, in vitro, and in silico approach
(Fakultet medicinskih nauka Univerziteta u Kragujevcu, 2023)
The aim of the conducted study was to develop new potential dual COX-2 and 5-LOX
inhibitors based on naproxen scaffold. We performed the evaluation of in vivo and in vitro
anti-inflammatory activity of newly synthesized ...
Investigation of albumin adsorption on DK-I-56-1 nanocrystals by dynamic light scattering
(8. Kongres farmaceuta Srbije; 12.-15. oktobar, Beograd, Srbija, 2022)
After parenteral administration, nanoparticles interact with different proteins,
forming a shell called corona, which further influence nanoparticles’ biodistribution. Protein
adsorption is affected by particle size and ...
Searching for the best way to incorporate the proprietary compound GL-II -73 into the nanoemulsion carrier for prospective parenteral application
(International Association of Physical Chemists, 2023)
Searching for the best way to incorporate the proprietary compound GL-II -73 into the nanoemulsion carrier for prospective parenteral application
Jelena Đoković1, Bojan Marković2, Dishary Sharmin3, James M Cook3, Miroslav ...
Preformulation and development of preliminary nanoemulsion carrier for patent protected compound GL-II-73
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Nanopharmaceuticals offer a good option to avoid
some of the difficulties that novel drug candidates
confront. They can be tailored to adjust their water
solubility, half-life, biodistribution, and govern the release
of ...