Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans
Аутори
Javorac, DraganaBaralić, Katarina
Marić, Đurđica
Mandić-Rajčević, Stefan
Đukić-Ćosić, Danijela
Bulat, Zorica
Buha-Đorđević, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in mal...es and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.
Кључне речи:
BLL / BMD / Endocrine effects / General populationИзвор:
Environmental Pollution, 2023, 316Издавач:
- Elsevier Ltd
Финансирање / пројекти:
DOI: 10.1016/j.envpol.2022.120428
ISSN: 0269-7491
PubMed: 36244500
WoS: 000878606000005
Scopus: 2-s2.0-85140440865
Институција/група
PharmacyTY - JOUR AU - Javorac, Dragana AU - Baralić, Katarina AU - Marić, Đurđica AU - Mandić-Rajčević, Stefan AU - Đukić-Ćosić, Danijela AU - Bulat, Zorica AU - Buha-Đorđević, Aleksandra PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4299 AB - Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low. PB - Elsevier Ltd T2 - Environmental Pollution T1 - Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans VL - 316 DO - 10.1016/j.envpol.2022.120428 ER -
@article{ author = "Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Mandić-Rajčević, Stefan and Đukić-Ćosić, Danijela and Bulat, Zorica and Buha-Đorđević, Aleksandra", year = "2023", abstract = "Exposure to low levels of a toxic metal lead (Pb) affects human health, and its effect as an endocrine disruptor has been reported. However, the precise role of Pb in endocrine health is still unclear because no dose-response relationship has been established for such an effect. The present study aimed to examine blood Pb levels (BLLs) in relation to serum levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and insulin in 435 nonoccupationally exposed Serbian subjects (218 women, 217 men, 18–94 years of age, mean age 48). In addition, benchmark dose (BMD) values were calculated for these endocrine endpoints using the PROAST 70.1 software. An explicit dose-response dependency between BLL and TSH, fT3, fT4, testosterone, and insulin serum levels was evident from BMD modelling. The results support the positive association between BLLs and serum insulin levels, with observed dose-response and calculated BMD values of 1.49 and 0.74 μg Pb/dL in males and females, respectively. Collectively, our findings reported potential endocrine-disrupting effects of Pb at the environmental exposure levels experienced by current Serbian population. They also strengthen the notion that the blood Pb threshold level for an endocrine effect is low.", publisher = "Elsevier Ltd", journal = "Environmental Pollution", title = "Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans", volume = "316", doi = "10.1016/j.envpol.2022.120428" }
Javorac, D., Baralić, K., Marić, Đ., Mandić-Rajčević, S., Đukić-Ćosić, D., Bulat, Z.,& Buha-Đorđević, A.. (2023). Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans. in Environmental Pollution Elsevier Ltd., 316. https://doi.org/10.1016/j.envpol.2022.120428
Javorac D, Baralić K, Marić Đ, Mandić-Rajčević S, Đukić-Ćosić D, Bulat Z, Buha-Đorđević A. Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans. in Environmental Pollution. 2023;316. doi:10.1016/j.envpol.2022.120428 .
Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Mandić-Rajčević, Stefan, Đukić-Ćosić, Danijela, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Exploring the endocrine disrupting potential of lead through benchmark modelling – Study in humans" in Environmental Pollution, 316 (2023), https://doi.org/10.1016/j.envpol.2022.120428 . .