New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
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2023
Authors
Buha-Đorđević, AleksandraMilovanović, Vesna
Ćurčić, Marijana
Antonijević-Miljaković, Evica
Bulat, Zorica
Đukić-Ćosić, Danijela
Janković, Saša
Vučinić, Slavica
Hayes, Wallace
Antonijević, Biljana
Article (Published version)
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The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach... use in future risk assessment.
Keywords:
Oxidative stress / Rats / Polychlorinated biphenyls / BMD concept / Dose-dependence / NephrotoxicitySource:
Environmental Research, 2023, 217Publisher:
- Elsevier Inc
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
- The animal study protocol was approved by the Ethics Committee of Military Medical Academy in Belgrade, Serbia (no. 9667–1/2011)
DOI: 10.1016/j.envres.2022.114829
ISSN: 0013-9351
PubMed: 36410460
WoS: 000895344600002
Scopus: 2-s2.0-85142765319
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Institution/Community
PharmacyTY - JOUR AU - Buha-Đorđević, Aleksandra AU - Milovanović, Vesna AU - Ćurčić, Marijana AU - Antonijević-Miljaković, Evica AU - Bulat, Zorica AU - Đukić-Ćosić, Danijela AU - Janković, Saša AU - Vučinić, Slavica AU - Hayes, Wallace AU - Antonijević, Biljana PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4326 AB - The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment. PB - Elsevier Inc T2 - Environmental Research T1 - New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model VL - 217 DO - 10.1016/j.envres.2022.114829 ER -
@article{ author = "Buha-Đorđević, Aleksandra and Milovanović, Vesna and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Bulat, Zorica and Đukić-Ćosić, Danijela and Janković, Saša and Vučinić, Slavica and Hayes, Wallace and Antonijević, Biljana", year = "2023", abstract = "The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.", publisher = "Elsevier Inc", journal = "Environmental Research", title = "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model", volume = "217", doi = "10.1016/j.envres.2022.114829" }
Buha-Đorđević, A., Milovanović, V., Ćurčić, M., Antonijević-Miljaković, E., Bulat, Z., Đukić-Ćosić, D., Janković, S., Vučinić, S., Hayes, W.,& Antonijević, B.. (2023). New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research Elsevier Inc., 217. https://doi.org/10.1016/j.envres.2022.114829
Buha-Đorđević A, Milovanović V, Ćurčić M, Antonijević-Miljaković E, Bulat Z, Đukić-Ćosić D, Janković S, Vučinić S, Hayes W, Antonijević B. New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research. 2023;217. doi:10.1016/j.envres.2022.114829 .
Buha-Đorđević, Aleksandra, Milovanović, Vesna, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Bulat, Zorica, Đukić-Ćosić, Danijela, Janković, Saša, Vučinić, Slavica, Hayes, Wallace, Antonijević, Biljana, "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model" in Environmental Research, 217 (2023), https://doi.org/10.1016/j.envres.2022.114829 . .