Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis
Аутори
Nikolić, InesSimić, Mitar
Pantelić, Ivana
Stojanović, Goran
Antić-Stanković, Jelena
Marković, Bojan
Savić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to
evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded
nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration
enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were
designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety
profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min
(continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and
5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the
total amount of curcumin that penetrated ...through the superficial skin layers ( in vivo tape stripping)
(Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly
more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions.
Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical
contribution in the field of dermal drug application.
Кључне речи:
curcumin / dermal drug delivery / iontophoresis / nanoemulsions / penetration enhancersИзвор:
Pharmaceutics, 2022, 14, 6Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics14061144
ISSN: 1999-4923
WoS: 000815886000001
Scopus: 2-s2.0-85131591387
Институција/група
PharmacyTY - JOUR AU - Nikolić, Ines AU - Simić, Mitar AU - Pantelić, Ivana AU - Stojanović, Goran AU - Antić-Stanković, Jelena AU - Marković, Bojan AU - Savić, Snežana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4328 AB - So far, various approaches have been proposed to improve dermal drug delivery. The use of chemical penetration enhancers has a long history of application, while methods based on the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min (continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and 5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping) (Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions. Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical contribution in the field of dermal drug application. PB - MDPI T2 - Pharmaceutics T1 - Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis VL - 14 IS - 6 DO - 10.3390/pharmaceutics14061144 ER -
@article{ author = "Nikolić, Ines and Simić, Mitar and Pantelić, Ivana and Stojanović, Goran and Antić-Stanković, Jelena and Marković, Bojan and Savić, Snežana", year = "2022", abstract = "So far, various approaches have been proposed to improve dermal drug delivery. The use of chemical penetration enhancers has a long history of application, while methods based on the electrical current (such as iontophoresis) stand out as promising “active” techniques. Aiming to evaluate the contribution of different approaches to dermal delivery, in this work curcumin-loaded nanoemulsions with and without monoterpenes (eucalyptol or pinene) as chemical penetration enhancers, and a custom-made adhesive dermal delivery system based on iontophoresis were designed and assessed. In an in vivo study applying skin bioengineering techniques, their safety profile was proven. Three examined iontophoresis protocols, with total skin exposure time of 15 min (continuous flow for 15 min (15-0); 3 min of continuous flow and 2 min pause (3-2; 5 cycles) and 5 min of continuous flow and 1 min pause (5-1; 3 cycles) were equally efficient in terms of the total amount of curcumin that penetrated through the superficial skin layers ( in vivo tape stripping) (Q3-2 = 7.04 ± 3.21 μg/cm2; Q5-1 = 6.66 ± 2.11 μg/cm2; Q15-0 = 6.96 ± 3.21 μg/cm2), significantly more efficient compared to the referent nanoemulsion and monoterpene-containing nanoemulsions. Further improvement of an efficient mobile adhesive system for iontophoresis would be a practical contribution in the field of dermal drug application.", publisher = "MDPI", journal = "Pharmaceutics", title = "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis", volume = "14", number = "6", doi = "10.3390/pharmaceutics14061144" }
Nikolić, I., Simić, M., Pantelić, I., Stojanović, G., Antić-Stanković, J., Marković, B.,& Savić, S.. (2022). Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics MDPI., 14(6). https://doi.org/10.3390/pharmaceutics14061144
Nikolić I, Simić M, Pantelić I, Stojanović G, Antić-Stanković J, Marković B, Savić S. Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. in Pharmaceutics. 2022;14(6). doi:10.3390/pharmaceutics14061144 .
Nikolić, Ines, Simić, Mitar, Pantelić, Ivana, Stojanović, Goran, Antić-Stanković, Jelena, Marković, Bojan, Savić, Snežana, "Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis" in Pharmaceutics, 14, no. 6 (2022), https://doi.org/10.3390/pharmaceutics14061144 . .