Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study
Authors
Baralić, KatarinaJavorac, Dragana
Marić, Đurđica
Đukić-Ćosić, Danijela
Bulat, Zorica
Antonijević-Miljaković, Evica
Anđelković, Milena
Antonijević, Biljana
Aschner, Michael
Buha-Đorđević, Aleksandra
Article (Published version)
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The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose–response modeling analysis was performed with the PROAST software version 70.1, showing the hormone levels as quantal data. The averaging technique was applied to compute the Benchmark dose (BMD) interval (BMDI), with benchmark response set at 10%. Dose-response relationships between metal/metalloid blood concentration and serum hormone levels were confirmed for all the investigated metals/metalloid ...and hormones. The narrowest BMDI was found for Cd-testosterone and Hg-LH pairs, indicative of high confidence in these estimates. Although further research is needed, the observed findings demonstrate that the BMD approach may prove to be significant in the dose–response modeling of human data.
Keywords:
BMD approach / Dose-response relationship / Toxic metals / Reproductive toxicity / Endocrine disruptionSource:
Environment International, 2022, 165Publisher:
- Elsevier B.V.
Funding / projects:
DOI: 10.1016/j.envint.2022.107313
ISSN: 0160-4120
WoS: 000806361300010
Scopus: 2-s2.0-85131042853
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PharmacyTY - JOUR AU - Baralić, Katarina AU - Javorac, Dragana AU - Marić, Đurđica AU - Đukić-Ćosić, Danijela AU - Bulat, Zorica AU - Antonijević-Miljaković, Evica AU - Anđelković, Milena AU - Antonijević, Biljana AU - Aschner, Michael AU - Buha-Đorđević, Aleksandra PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4351 AB - The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose–response modeling analysis was performed with the PROAST software version 70.1, showing the hormone levels as quantal data. The averaging technique was applied to compute the Benchmark dose (BMD) interval (BMDI), with benchmark response set at 10%. Dose-response relationships between metal/metalloid blood concentration and serum hormone levels were confirmed for all the investigated metals/metalloid and hormones. The narrowest BMDI was found for Cd-testosterone and Hg-LH pairs, indicative of high confidence in these estimates. Although further research is needed, the observed findings demonstrate that the BMD approach may prove to be significant in the dose–response modeling of human data. PB - Elsevier B.V. T2 - Environment International T1 - Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study VL - 165 DO - 10.1016/j.envint.2022.107313 ER -
@article{ author = "Baralić, Katarina and Javorac, Dragana and Marić, Đurđica and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević-Miljaković, Evica and Anđelković, Milena and Antonijević, Biljana and Aschner, Michael and Buha-Đorđević, Aleksandra", year = "2022", abstract = "The main objective of this research was to conduct a dose–response modeling between the internal dose of measured blood Cd, As, Hg, Ni, and Cr and hormonal response of serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The study included 207 male participants from subjects of 5 different cohorts (patients with prostate, testicular, and pancreatic cancer, patients suffering from various thyroid and metabolic disorders, as well as healthy volunteers), enrolled from January 2019 to May 2021 at the Clinical Centre of Serbia in Belgrade, Serbia. Benchmark dose–response modeling analysis was performed with the PROAST software version 70.1, showing the hormone levels as quantal data. The averaging technique was applied to compute the Benchmark dose (BMD) interval (BMDI), with benchmark response set at 10%. Dose-response relationships between metal/metalloid blood concentration and serum hormone levels were confirmed for all the investigated metals/metalloid and hormones. The narrowest BMDI was found for Cd-testosterone and Hg-LH pairs, indicative of high confidence in these estimates. Although further research is needed, the observed findings demonstrate that the BMD approach may prove to be significant in the dose–response modeling of human data.", publisher = "Elsevier B.V.", journal = "Environment International", title = "Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study", volume = "165", doi = "10.1016/j.envint.2022.107313" }
Baralić, K., Javorac, D., Marić, Đ., Đukić-Ćosić, D., Bulat, Z., Antonijević-Miljaković, E., Anđelković, M., Antonijević, B., Aschner, M.,& Buha-Đorđević, A.. (2022). Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study. in Environment International Elsevier B.V.., 165. https://doi.org/10.1016/j.envint.2022.107313
Baralić K, Javorac D, Marić Đ, Đukić-Ćosić D, Bulat Z, Antonijević-Miljaković E, Anđelković M, Antonijević B, Aschner M, Buha-Đorđević A. Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study. in Environment International. 2022;165. doi:10.1016/j.envint.2022.107313 .
Baralić, Katarina, Javorac, Dragana, Marić, Đurđica, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević-Miljaković, Evica, Anđelković, Milena, Antonijević, Biljana, Aschner, Michael, Buha-Đorđević, Aleksandra, "Benchmark dose approach in investigating the relationship between blood metal levels and reproductive hormones: Data set from human study" in Environment International, 165 (2022), https://doi.org/10.1016/j.envint.2022.107313 . .