Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine
Doprinos razvoju nove mikrozapreminske/mikro-koncentracione kvantitativne analize - određivanje morfina
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Pejić, NatašaAnić, Slobodan
Mijatović, Miroslav
Milenković, Svetozar
Ćirić, Jasna
Grozdić, Tomislav D.
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The results of investigation of a new kinetic analytical method for microquantitative (microconcentration/microvolume) determination of morphine is given. This method is based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky reaction as the oscillatory reaction system being in a stable non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor at T=310 K. The response of the matrix system to perturbations by different concentrations of morphine ethanolic solutions is followed by a Pt-electrode. In the concentration range from 0.11 to 2.90 μg mL-1 (3.14´10-7 - 7.65´10-6 mol dm-3) of morphine, a linear response of the maximal potential shift versus the logarithm concentrations of morphine is found. The average relative standard deviation of morphine determination in 5% ethanol solution is 5,4%. The detection limit of the morphine concentration is 41 ng mL-1. The accuracy of the method is 98.5%. T...he method is simple, reliable and cheap.
Daju se rezultati istraživanja nove kinetičke metode mikrozapreminskog/mikrokoncentracionog određivanja morfina. Ona se zasniva na potenciometrijskom praćenju odgovora analitičke matrice - nelinearnog reakcionog sistema Bray-Liebhafsky u neravnotežnom stacionarnom stanju u blizini bifurkacione tačke na impulsne perturbacije različitim količinama alkoholnog rastvora alkaloida morfina. U uslovima korišćene izotermalne (T=310 K) analitičke matrice, koja je realizovana u protočnom dobromešajućem reaktoru, promena potencijala Pt-oksidoredukcione elektrode izazvana perturbacijom sa morfinom u odnosu na potencijal koji karakteriše neravnotežno stacionarno stanje neperturbovane analitičke matrice, pokazuje linearnu zavisnost od logaritma količine morfina u području od 0,11-2,90 μg mL-1 (3,14x10-7 do 7,65x10-6 mol dm-3) morfina. Pri tome je srednja relativna standardna devijacija određivanja morfina u 5% alkoholnom rastvoru 5,4%, detekcioni limit 41 ng mL-1, a tačnost 98,5%. Metoda je jednostav...na pouzdana i jeftina.
Keywords:
morphine / microvolume/microconcentration analyze / kinetic analytical method / Bray-Liebhafsky oscillatory reaction / morfin / mikrozapreminska/mikrokoncentraciona analiza / kinetička metoda / Bray-Liebhafsky reakcijaSource:
Nauka, tehnika, bezbednost, 2003, 13, 1, 67-74Publisher:
- Institut bezbednosti, Beograd
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PharmacyTY - JOUR AU - Pejić, Nataša AU - Anić, Slobodan AU - Mijatović, Miroslav AU - Milenković, Svetozar AU - Ćirić, Jasna AU - Grozdić, Tomislav D. PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/467 AB - The results of investigation of a new kinetic analytical method for microquantitative (microconcentration/microvolume) determination of morphine is given. This method is based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky reaction as the oscillatory reaction system being in a stable non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor at T=310 K. The response of the matrix system to perturbations by different concentrations of morphine ethanolic solutions is followed by a Pt-electrode. In the concentration range from 0.11 to 2.90 μg mL-1 (3.14´10-7 - 7.65´10-6 mol dm-3) of morphine, a linear response of the maximal potential shift versus the logarithm concentrations of morphine is found. The average relative standard deviation of morphine determination in 5% ethanol solution is 5,4%. The detection limit of the morphine concentration is 41 ng mL-1. The accuracy of the method is 98.5%. The method is simple, reliable and cheap. AB - Daju se rezultati istraživanja nove kinetičke metode mikrozapreminskog/mikrokoncentracionog određivanja morfina. Ona se zasniva na potenciometrijskom praćenju odgovora analitičke matrice - nelinearnog reakcionog sistema Bray-Liebhafsky u neravnotežnom stacionarnom stanju u blizini bifurkacione tačke na impulsne perturbacije različitim količinama alkoholnog rastvora alkaloida morfina. U uslovima korišćene izotermalne (T=310 K) analitičke matrice, koja je realizovana u protočnom dobromešajućem reaktoru, promena potencijala Pt-oksidoredukcione elektrode izazvana perturbacijom sa morfinom u odnosu na potencijal koji karakteriše neravnotežno stacionarno stanje neperturbovane analitičke matrice, pokazuje linearnu zavisnost od logaritma količine morfina u području od 0,11-2,90 μg mL-1 (3,14x10-7 do 7,65x10-6 mol dm-3) morfina. Pri tome je srednja relativna standardna devijacija određivanja morfina u 5% alkoholnom rastvoru 5,4%, detekcioni limit 41 ng mL-1, a tačnost 98,5%. Metoda je jednostavna pouzdana i jeftina. PB - Institut bezbednosti, Beograd T2 - Nauka, tehnika, bezbednost T1 - Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine T1 - Doprinos razvoju nove mikrozapreminske/mikro-koncentracione kvantitativne analize - određivanje morfina VL - 13 IS - 1 SP - 67 EP - 74 UR - https://hdl.handle.net/21.15107/rcub_farfar_467 ER -
@article{ author = "Pejić, Nataša and Anić, Slobodan and Mijatović, Miroslav and Milenković, Svetozar and Ćirić, Jasna and Grozdić, Tomislav D.", year = "2003", abstract = "The results of investigation of a new kinetic analytical method for microquantitative (microconcentration/microvolume) determination of morphine is given. This method is based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky reaction as the oscillatory reaction system being in a stable non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor at T=310 K. The response of the matrix system to perturbations by different concentrations of morphine ethanolic solutions is followed by a Pt-electrode. In the concentration range from 0.11 to 2.90 μg mL-1 (3.14´10-7 - 7.65´10-6 mol dm-3) of morphine, a linear response of the maximal potential shift versus the logarithm concentrations of morphine is found. The average relative standard deviation of morphine determination in 5% ethanol solution is 5,4%. The detection limit of the morphine concentration is 41 ng mL-1. The accuracy of the method is 98.5%. The method is simple, reliable and cheap., Daju se rezultati istraživanja nove kinetičke metode mikrozapreminskog/mikrokoncentracionog određivanja morfina. Ona se zasniva na potenciometrijskom praćenju odgovora analitičke matrice - nelinearnog reakcionog sistema Bray-Liebhafsky u neravnotežnom stacionarnom stanju u blizini bifurkacione tačke na impulsne perturbacije različitim količinama alkoholnog rastvora alkaloida morfina. U uslovima korišćene izotermalne (T=310 K) analitičke matrice, koja je realizovana u protočnom dobromešajućem reaktoru, promena potencijala Pt-oksidoredukcione elektrode izazvana perturbacijom sa morfinom u odnosu na potencijal koji karakteriše neravnotežno stacionarno stanje neperturbovane analitičke matrice, pokazuje linearnu zavisnost od logaritma količine morfina u području od 0,11-2,90 μg mL-1 (3,14x10-7 do 7,65x10-6 mol dm-3) morfina. Pri tome je srednja relativna standardna devijacija određivanja morfina u 5% alkoholnom rastvoru 5,4%, detekcioni limit 41 ng mL-1, a tačnost 98,5%. Metoda je jednostavna pouzdana i jeftina.", publisher = "Institut bezbednosti, Beograd", journal = "Nauka, tehnika, bezbednost", title = "Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine, Doprinos razvoju nove mikrozapreminske/mikro-koncentracione kvantitativne analize - određivanje morfina", volume = "13", number = "1", pages = "67-74", url = "https://hdl.handle.net/21.15107/rcub_farfar_467" }
Pejić, N., Anić, S., Mijatović, M., Milenković, S., Ćirić, J.,& Grozdić, T. D.. (2003). Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine. in Nauka, tehnika, bezbednost Institut bezbednosti, Beograd., 13(1), 67-74. https://hdl.handle.net/21.15107/rcub_farfar_467
Pejić N, Anić S, Mijatović M, Milenković S, Ćirić J, Grozdić TD. Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine. in Nauka, tehnika, bezbednost. 2003;13(1):67-74. https://hdl.handle.net/21.15107/rcub_farfar_467 .
Pejić, Nataša, Anić, Slobodan, Mijatović, Miroslav, Milenković, Svetozar, Ćirić, Jasna, Grozdić, Tomislav D., "Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine" in Nauka, tehnika, bezbednost, 13, no. 1 (2003):67-74, https://hdl.handle.net/21.15107/rcub_farfar_467 .