Претраживање
Приказ резултата 1-6 од 6
Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site / Doking studije nekih jedinjenja sa pirazolom u aktivnom mestu ciklooksigenaze-2
(Savez farmaceutskih udruženja Srbije (SFUS), 2023)
Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and
diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors
target cyclooxygenase-2, which is ...
Discovery of Novel Thiophene/Hydrazones: In Vitro and In Silico Studies against Pancreatic Cancer
(MDPI, 2023)
Cancer is the disease with the highest mortality. Drug studies contribute to promising treatments; however there is an urgent need for selective drug candidates. Pancreatic cancer is difficult to treat and the cancer ...
Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors
(MDPI, 2023)
Various dual inhibitors of COX-2 and 5-LOX enzymes have been developed so far in order to obtain more effective and safer anti-inflammatory drugs. The aim of this study was to design and synthesize new dual COX-2 and 5-LOX ...
Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
(MDPI, 2023)
The aim of the study was a synthesis and investigation of the dose-dependent anti-inflammatory effect of new thiourea derivatives of naproxen with selected aromatic amines and esters of aromatic amino acids. The results ...
Selected thiourea derivatives of naproxen as potential anti-inflammatory agents: in vivo, in vitro, and in silico approach
(Fakultet medicinskih nauka Univerziteta u Kragujevcu, 2023)
The aim of the conducted study was to develop new potential dual COX-2 and 5-LOX
inhibitors based on naproxen scaffold. We performed the evaluation of in vivo and in vitro
anti-inflammatory activity of newly synthesized ...
Synthesis and investigation of enzyme inhibition of potential dual COX-2 and 5-LOX inhibitors
(European Federation for Medicinal chemistry and Chemical biology (EFMC), 2023)
The pathogenesis and progression of a various diseases, such as cancer, rheumatoid arthritis, autoimmune, cardiovascular and neurodegenerative diseases, are closely related to chronic inflammatory processes. ...