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Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application
dc.creator | Brborić, Jasmina | |
dc.creator | Klisić, Aleksandra | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Delogu, Giovanna | |
dc.creator | Gjorgieva Ackova, Darinka | |
dc.creator | Kostić, Kristina | |
dc.creator | Dettori, Maria Antonietta | |
dc.creator | Fabbri, Davide | |
dc.creator | Carta, Paola | |
dc.creator | Saso, Luciano | |
dc.date.accessioned | 2023-08-17T09:48:40Z | |
dc.date.available | 2023-08-17T09:48:40Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1734-1922 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/4964 | |
dc.description.abstract | Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform in vitro screening of natural and natural-like phenol monomers and their C2-symmetric dimers (hydroxylated biphenyls) in order to identify those representatives whose pharmacophores have the strongest antioxidant and the lowest prooxidant activity. Material and methods: Antioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were evaluated in vitro. Different (red/ ox) assays were used to measure their total oxidative potential (TOP), their total antioxidative capacity (TAC), the pro-oxidative-antioxidant balance (PAB) and total SH-group content (SHG) in a biologically relevant environment. The Pro-oxidative Score, Antioxidative Score and the Oxy Score were also calculated. Trolox, a water soluble analogue of α-tocopherol, was used as a positive control. Results: In an assay consisting of pooled human serum, 6 of the 36 compounds showed significant antioxidant activity (compounds 6, 7, 12, 13, 26, and 27), whereas 4 showed extremely weak antioxidant activity (compounds 2, 29, 30, and 31). Within the 36 compounds comprising zingerone, dehydrozingerone, aurone, chalcone, and magnolol derivatives, in both monomeric and dimeric forms, the 2 compounds that indicated the highest antioxidant activity were dehydrozingerone derivatives (compounds 6 and 12). Trolox’s activity was found between the strong and weak antioxidant compounds analysed in our study. Conclusions: In this study selected dehydrozingerones were identified as good candidates for in-depth testing of their biological behaviour and for possible precursors for synthesis of novel polyphenolic molecules with potential therapeutic applications. | |
dc.publisher | Termedia Publishing House | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.relation | Sardinia Region, Italy (Project FSC 2014-2020, RASSR73282) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Archives of Medical Science | |
dc.subject | oxidative stress | |
dc.subject | polyphenols | |
dc.subject | dehydrozingerone | |
dc.subject | hydroxylated biphenyls | |
dc.subject | Trolox | |
dc.title | Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application | |
dc.type | article | |
dc.rights.license | BY-NC-SA | |
dc.citation.volume | 19 | |
dc.citation.issue | 3 | |
dc.citation.spage | 651 | |
dc.citation.epage | 671 | |
dc.citation.rank | M22~ | |
dc.identifier.wos | 001019595200013 | |
dc.identifier.doi | 10.5114/aoms/135379 | |
dc.identifier.pmid | 37313202 | |
dc.identifier.scopus | 2-s2.0-85119056816 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/13646/Natural_and_natural_pub_2023.pdf | |
dc.type.version | publishedVersion |