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Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling
| dc.creator | Nikolić, Katarina | |
| dc.creator | Vučićević, Jelica | |
| dc.creator | Popović, Marija | |
| dc.creator | Filipić, Slavica | |
| dc.creator | Obradović, Darija | |
| dc.creator | Dobričić, Vladimir | |
| dc.creator | Agbaba, Danica | |
| dc.date.accessioned | 2023-09-14T13:19:42Z | |
| dc.date.available | 2023-09-14T13:19:42Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 2217-8767 | |
| dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5027 | |
| dc.description.abstract | Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both alpha2-adrenoreceptors (alpha2-AR) and imidazoline receptors (IRs) (1, 2). The main aims of this study were to evaluate Blood-Brain Barrier (BBB) permeability (Pe) of 18 IRs/alpha-ARs ligands and 22 Central Nervous System (CNS) drugs using Parallel Artificial Membrane Permeability Assay (PAMPA) and Biopartitioning Micellar Chromatography (BMC), and than to develop the Quantitative-Structure-Permeability Relationship (QSPR) models useful for prediction BBB permeability of related IRs/alpha- ARs ligands. | sr |
| dc.language.iso | sr | sr |
| dc.language.iso | en | sr |
| dc.publisher | Savez farmaceutskih udruženja Srbije, Beograd | sr |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | sr |
| dc.rights | openAccess | sr |
| dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
| dc.source | Arhiv za farmaciju, Special Issue, Book of Abstracts, 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia | sr |
| dc.title | Study of bloodbrain barrier permeation using parallel artificial membrane permeability assay and quantitative structure permeability relationship modeling | sr |
| dc.type | conferenceObject | sr |
| dc.rights.license | BY-SA | sr |
| dc.citation.volume | 66 | |
| dc.citation.spage | 25 | |
| dc.citation.epage | 26 | |
| dc.description.other | 11 Central European Symposium on Pharmaceutical Technology, September 22 – 24, 2016 Belgrade, Serbia | sr |
| dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/13836/Study_of_bloodbrain_pub_2016.pdf | |
| dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_5027 | |
| dc.type.version | publishedVersion | sr |
