A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability to mechanistically explain how drug properties,
product quality attributes and physiological factors
influence the in vivo drug performance. To better specify
the application field of these models and highlight the link
between in vitro dissolution and drug’s in vivo behavior, a
novel term, physiologically based biopharmaceutics
modeling (PBBM), was recently introduced.
The versatility of application of these models is
perceived through the growth in the number of scientific
publications that include the use of PBPK/PBBM
(Krstevska et al, 2022). In the present study, the use of
PBPK/PBBM across the publications from the past decade
was analyzed, with the focus on the application of these
models in pharmaceutical/formulation development.
Извор:
Macedonian Pharmaceutical Bulletin, 2023, 69, Suppl 1, 145-146Издавач:
- Macedonian Pharmaceutical Association
- Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
Напомена:
- 14th Central European Symposium on Pharmaceutical Technology, 28th - 30th September, Ohrid, N. Macedonia, 2023
Институција/група
PharmacyTY - CONF AU - Krstevska, Aleksandra AU - Đuriš, Jelena AU - Ibrić, Svetlana AU - Cvijić, Sandra PY - 2023 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5068 AB - Physiologically based pharmacokinetic (PBPK) modeling is an evolving tool that has a profound impact on drug discovery and formulation development processes. A major advantage of PBPK models is that they have the ability to mechanistically explain how drug properties, product quality attributes and physiological factors influence the in vivo drug performance. To better specify the application field of these models and highlight the link between in vitro dissolution and drug’s in vivo behavior, a novel term, physiologically based biopharmaceutics modeling (PBBM), was recently introduced. The versatility of application of these models is perceived through the growth in the number of scientific publications that include the use of PBPK/PBBM (Krstevska et al, 2022). In the present study, the use of PBPK/PBBM across the publications from the past decade was analyzed, with the focus on the application of these models in pharmaceutical/formulation development. PB - Macedonian Pharmaceutical Association PB - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy C3 - Macedonian Pharmaceutical Bulletin T1 - A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development VL - 69 IS - Suppl 1 SP - 145 EP - 146 DO - 10.33320/maced.pharm.bull.2023.69.03.071 ER -
@conference{ author = "Krstevska, Aleksandra and Đuriš, Jelena and Ibrić, Svetlana and Cvijić, Sandra", year = "2023", abstract = "Physiologically based pharmacokinetic (PBPK) modeling is an evolving tool that has a profound impact on drug discovery and formulation development processes. A major advantage of PBPK models is that they have the ability to mechanistically explain how drug properties, product quality attributes and physiological factors influence the in vivo drug performance. To better specify the application field of these models and highlight the link between in vitro dissolution and drug’s in vivo behavior, a novel term, physiologically based biopharmaceutics modeling (PBBM), was recently introduced. The versatility of application of these models is perceived through the growth in the number of scientific publications that include the use of PBPK/PBBM (Krstevska et al, 2022). In the present study, the use of PBPK/PBBM across the publications from the past decade was analyzed, with the focus on the application of these models in pharmaceutical/formulation development.", publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy", journal = "Macedonian Pharmaceutical Bulletin", title = "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development", volume = "69", number = "Suppl 1", pages = "145-146", doi = "10.33320/maced.pharm.bull.2023.69.03.071" }
Krstevska, A., Đuriš, J., Ibrić, S.,& Cvijić, S.. (2023). A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin Macedonian Pharmaceutical Association., 69(Suppl 1), 145-146. https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071
Krstevska A, Đuriš J, Ibrić S, Cvijić S. A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):145-146. doi:10.33320/maced.pharm.bull.2023.69.03.071 .
Krstevska, Aleksandra, Đuriš, Jelena, Ibrić, Svetlana, Cvijić, Sandra, "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):145-146, https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071 . .