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Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
dc.creator | Jovanović, MS | |
dc.creator | Popović, Gordana | |
dc.creator | Kapetanović, Vera | |
dc.creator | Orlić, M | |
dc.creator | Vladimirov, S | |
dc.date.accessioned | 2019-09-02T10:59:02Z | |
dc.date.available | 2019-09-02T10:59:02Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/516 | |
dc.description.abstract | In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.subject | iminodiacetic acid | en |
dc.subject | METHYLIODIDA | en |
dc.subject | ionization constants | en |
dc.subject | potentiometry | en |
dc.title | Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Капетановић, Вера; Владимиров, С; Орлић, М; Јовановић, МС; Поповић, Гордана; | |
dc.citation.volume | 35 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1257 | |
dc.citation.epage | 1261 | |
dc.citation.other | 35(5): 1257-1261 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000224261500027 | |
dc.identifier.doi | 10.1016/j.jpba.2004.03.009 | |
dc.identifier.pmid | 15336370 | |
dc.identifier.scopus | 2-s2.0-4344623397 | |
dc.type.version | publishedVersion |