The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients
Samo za registrovane korisnike
2024
Autori
Milošević, TamaraSopić, Miron
Vekić, Jelena
Guzonjić, Azra
Vujčić, Sanja
Pešić, Snežana
Miljković-Trailović, Milica
Naumović, Radomir
Kotur-Stevuljević, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Purpose: End-stage renal disease patients on chronic hemodialysis (HD) have a shortened life expectancy compared to the general population. The aim of this study was to evaluate a possible link between three new and emerging factors in renal pathophysiology: Klotho protein, telomere length in peripheral blood mononuclear cells (TL) and redox status parameters before HD (bHD) and after HD (aHD), and to test mortality prediction capability of these emerging parameters in a population of HD patients. Methods: The study included 130 adult patients with average age 66 (54–72), on HD (3 times per week; 4–5 h per session). Klotho level, TL, routine laboratory parameters, dialysis adequacy and redox status parameters: advanced oxidation protein products (AOPP), prooxidant–antioxidant balance (PAB), superoxide anion (O2.−), malondialdehyde (MDA), ischemia-modified albumin (IMA), total sulfhydryl group content (SHG), and superoxide dismutase (SOD) were determined. Results: Klotho concentration w...as significantly higher aHD; 68.2 (22.6–152.9) vs. bHD 64.2 (25.5–119.8) (p = 0.027). The observed increase in TL was not statistically significant. AOPP, PAB, SHG, and SOD activity were significantly increased aHD (p > 0.001). The patients with the highest mortality risk score (MRS) had significantly higher PAB bHD (p = 0.002). Significantly lower O2.− (p < 0.001), SHG content (p = 0.072), and IMA (p = 0.002) aHD were found in patients with the lowest MRS values. Principal component analysis revealed redox balance-Klotho factor as a significant predictor of high mortality risk (p = 0.014). Conclusion: Decreased Klotho and TL attrition as well as redox status disturbance could be connected with higher mortality rate in HD patients.
Ključne reči:
Oxidative stress / Hemodialysis / Klotho protein / TelomeresIzvor:
International Urology and Nephrology, 2024, 56, 2, 615-623Izdavač:
- Springer Science and Business Media B.V.
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
DOI: 10.1007/s11255-023-03696-w
ISSN: 0301-1623
PubMed: 37410303
WoS: 001023406400001
Scopus: 2-s2.0-85164111947
Institucija/grupa
PharmacyTY - JOUR AU - Milošević, Tamara AU - Sopić, Miron AU - Vekić, Jelena AU - Guzonjić, Azra AU - Vujčić, Sanja AU - Pešić, Snežana AU - Miljković-Trailović, Milica AU - Naumović, Radomir AU - Kotur-Stevuljević, Jelena PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5414 AB - Purpose: End-stage renal disease patients on chronic hemodialysis (HD) have a shortened life expectancy compared to the general population. The aim of this study was to evaluate a possible link between three new and emerging factors in renal pathophysiology: Klotho protein, telomere length in peripheral blood mononuclear cells (TL) and redox status parameters before HD (bHD) and after HD (aHD), and to test mortality prediction capability of these emerging parameters in a population of HD patients. Methods: The study included 130 adult patients with average age 66 (54–72), on HD (3 times per week; 4–5 h per session). Klotho level, TL, routine laboratory parameters, dialysis adequacy and redox status parameters: advanced oxidation protein products (AOPP), prooxidant–antioxidant balance (PAB), superoxide anion (O2.−), malondialdehyde (MDA), ischemia-modified albumin (IMA), total sulfhydryl group content (SHG), and superoxide dismutase (SOD) were determined. Results: Klotho concentration was significantly higher aHD; 68.2 (22.6–152.9) vs. bHD 64.2 (25.5–119.8) (p = 0.027). The observed increase in TL was not statistically significant. AOPP, PAB, SHG, and SOD activity were significantly increased aHD (p > 0.001). The patients with the highest mortality risk score (MRS) had significantly higher PAB bHD (p = 0.002). Significantly lower O2.− (p < 0.001), SHG content (p = 0.072), and IMA (p = 0.002) aHD were found in patients with the lowest MRS values. Principal component analysis revealed redox balance-Klotho factor as a significant predictor of high mortality risk (p = 0.014). Conclusion: Decreased Klotho and TL attrition as well as redox status disturbance could be connected with higher mortality rate in HD patients. PB - Springer Science and Business Media B.V. T2 - International Urology and Nephrology T1 - The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients VL - 56 IS - 2 SP - 615 EP - 623 DO - 10.1007/s11255-023-03696-w ER -
@article{ author = "Milošević, Tamara and Sopić, Miron and Vekić, Jelena and Guzonjić, Azra and Vujčić, Sanja and Pešić, Snežana and Miljković-Trailović, Milica and Naumović, Radomir and Kotur-Stevuljević, Jelena", year = "2024", abstract = "Purpose: End-stage renal disease patients on chronic hemodialysis (HD) have a shortened life expectancy compared to the general population. The aim of this study was to evaluate a possible link between three new and emerging factors in renal pathophysiology: Klotho protein, telomere length in peripheral blood mononuclear cells (TL) and redox status parameters before HD (bHD) and after HD (aHD), and to test mortality prediction capability of these emerging parameters in a population of HD patients. Methods: The study included 130 adult patients with average age 66 (54–72), on HD (3 times per week; 4–5 h per session). Klotho level, TL, routine laboratory parameters, dialysis adequacy and redox status parameters: advanced oxidation protein products (AOPP), prooxidant–antioxidant balance (PAB), superoxide anion (O2.−), malondialdehyde (MDA), ischemia-modified albumin (IMA), total sulfhydryl group content (SHG), and superoxide dismutase (SOD) were determined. Results: Klotho concentration was significantly higher aHD; 68.2 (22.6–152.9) vs. bHD 64.2 (25.5–119.8) (p = 0.027). The observed increase in TL was not statistically significant. AOPP, PAB, SHG, and SOD activity were significantly increased aHD (p > 0.001). The patients with the highest mortality risk score (MRS) had significantly higher PAB bHD (p = 0.002). Significantly lower O2.− (p < 0.001), SHG content (p = 0.072), and IMA (p = 0.002) aHD were found in patients with the lowest MRS values. Principal component analysis revealed redox balance-Klotho factor as a significant predictor of high mortality risk (p = 0.014). Conclusion: Decreased Klotho and TL attrition as well as redox status disturbance could be connected with higher mortality rate in HD patients.", publisher = "Springer Science and Business Media B.V.", journal = "International Urology and Nephrology", title = "The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients", volume = "56", number = "2", pages = "615-623", doi = "10.1007/s11255-023-03696-w" }
Milošević, T., Sopić, M., Vekić, J., Guzonjić, A., Vujčić, S., Pešić, S., Miljković-Trailović, M., Naumović, R.,& Kotur-Stevuljević, J.. (2024). The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients. in International Urology and Nephrology Springer Science and Business Media B.V.., 56(2), 615-623. https://doi.org/10.1007/s11255-023-03696-w
Milošević T, Sopić M, Vekić J, Guzonjić A, Vujčić S, Pešić S, Miljković-Trailović M, Naumović R, Kotur-Stevuljević J. The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients. in International Urology and Nephrology. 2024;56(2):615-623. doi:10.1007/s11255-023-03696-w .
Milošević, Tamara, Sopić, Miron, Vekić, Jelena, Guzonjić, Azra, Vujčić, Sanja, Pešić, Snežana, Miljković-Trailović, Milica, Naumović, Radomir, Kotur-Stevuljević, Jelena, "The influence of Klotho protein and prooxidant–antioxidant balance combination on the mortality of HD patients" in International Urology and Nephrology, 56, no. 2 (2024):615-623, https://doi.org/10.1007/s11255-023-03696-w . .