Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent
Authorized Users Only
2024
Authors
Tasić, GordanaMitrović, Nikola
Simić, Milena
Koravović, Mladen
Jovanović, Predrag
Petković, Miloš
Jovanović, Miloš
Ivković, Branka
Savić, Vladimir
Article (Published version)
Metadata
Show full item recordAbstract
Hydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%).
Source:
Journal Heterocyclic Chemistry, 2024Publisher:
- Wiley Periodicals LLC.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
DOI: 10.1002/jhet.4802
ISSN: 0022-152X
WoS: 001181439100001
Scopus: 2-s2.0-85187113166
Collections
Institution/Community
PharmacyTY - JOUR AU - Tasić, Gordana AU - Mitrović, Nikola AU - Simić, Milena AU - Koravović, Mladen AU - Jovanović, Predrag AU - Petković, Miloš AU - Jovanović, Miloš AU - Ivković, Branka AU - Savić, Vladimir PY - 2024 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5556 AB - Hydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N-Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to good yields (40%–77%). PB - Wiley Periodicals LLC. T2 - Journal Heterocyclic Chemistry T1 - Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent DO - 10.1002/jhet.4802 ER -
@article{ author = "Tasić, Gordana and Mitrović, Nikola and Simić, Milena and Koravović, Mladen and Jovanović, Predrag and Petković, Miloš and Jovanović, Miloš and Ivković, Branka and Savić, Vladimir", year = "2024", abstract = "Hydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N-Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to good yields (40%–77%).", publisher = "Wiley Periodicals LLC.", journal = "Journal Heterocyclic Chemistry", title = "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent", doi = "10.1002/jhet.4802" }
Tasić, G., Mitrović, N., Simić, M., Koravović, M., Jovanović, P., Petković, M., Jovanović, M., Ivković, B.,& Savić, V.. (2024). Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry Wiley Periodicals LLC... https://doi.org/10.1002/jhet.4802
Tasić G, Mitrović N, Simić M, Koravović M, Jovanović P, Petković M, Jovanović M, Ivković B, Savić V. Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry. 2024;. doi:10.1002/jhet.4802 .
Tasić, Gordana, Mitrović, Nikola, Simić, Milena, Koravović, Mladen, Jovanović, Predrag, Petković, Miloš, Jovanović, Miloš, Ivković, Branka, Savić, Vladimir, "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent" in Journal Heterocyclic Chemistry (2024), https://doi.org/10.1002/jhet.4802 . .